Title:
METHOD FOR SCREENING CDKAL1 INHIBITOR THERAPEUTIC AGENT OF ATHEROSCLEROSIS, THERAPEUTIC REACTIVITY PREDICTION BIOMARKER FOR CDKAL1 INHIBITOR THERAPEUTIC AGENT, COMPOSITION, AND KIT
Document Type and Number:
WIPO Patent Application WO/2024/010424
Kind Code:
A1
Abstract:
The present invention relates to a method for screening a therapeutic agent for atherosclerosis, a method for providing information necessary for predicting therapeutic reactivity, a biomarker, a composition, and a kit. Specifically, at least one protein selected from the group consisting of SR-B1, hepatic lipase (HL) and endothelial lipase (EL), or a gene encoding the protein, is presented as a biomarker, and can be used to screen a therapeutic agent for atherosclerosis, predict the therapeutic reactivity of a Cdkal1 inhibitor therapeutic agent, and improve HDL metabolism and vascular pathology.
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Inventors:
LEE SANG HAK (KR)
AN DAN BI (KR)
ANN SOO JIN (KR)
AN DAN BI (KR)
ANN SOO JIN (KR)
Application Number:
PCT/KR2023/009694
Publication Date:
January 11, 2024
Filing Date:
July 07, 2023
Export Citation:
Assignee:
UIF UNIV INDUSTRY FOUNDATION YONSEI UNIV (KR)
International Classes:
C12Q1/6883; G01N33/68
Foreign References:
| JP2004000101A | 2004-01-08 | |||
| CN110205375A | 2019-09-06 | |||
| KR20170107934A | 2017-09-26 |
Other References:
LEE SANG HAK: "Investigating molecular effect and mechanism of CDKAL1 in lipoprotein metabolism by using genetically-engineered mouse", BASIC RESEARCH FINAL REPORT, 23 March 2022 (2022-03-23), pages 1 - 29, XP093126487
CHEON EUN JEONG, CHA DO HYEON, CHO SUNG KWEON, NOH HYE-MIN, PARK SUNGHA, KANG SEOK-MIN, GEE HEON YUNG, LEE SANG-HAK: "Novel association between CDKAL1 and cholesterol efflux capacity: Replication after GWAS-based discovery", ATHEROSCLEROSIS, ELSEVIER, AMSTERDAM, NL, vol. 273, 1 June 2018 (2018-06-01), AMSTERDAM, NL , pages 21 - 27, XP093126490, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.04.011
AN DAN BI, ANN SOO-JIN, SEOK SEUNGMIN, KANG YURA, LEE SANG-HAK: "Hepatic Cdkal1 deletion regulates HDL catabolism and promotes reverse cholesterol transport", ATHEROSCLEROSIS, ELSEVIER, AMSTERDAM, NL, vol. 375, 1 June 2023 (2023-06-01), AMSTERDAM, NL , pages 21 - 29, XP093126499, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2023.05.012
CHEON EUN JEONG, CHA DO HYEON, CHO SUNG KWEON, NOH HYE-MIN, PARK SUNGHA, KANG SEOK-MIN, GEE HEON YUNG, LEE SANG-HAK: "Novel association between CDKAL1 and cholesterol efflux capacity: Replication after GWAS-based discovery", ATHEROSCLEROSIS, ELSEVIER, AMSTERDAM, NL, vol. 273, 1 June 2018 (2018-06-01), AMSTERDAM, NL , pages 21 - 27, XP093126490, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.04.011
AN DAN BI, ANN SOO-JIN, SEOK SEUNGMIN, KANG YURA, LEE SANG-HAK: "Hepatic Cdkal1 deletion regulates HDL catabolism and promotes reverse cholesterol transport", ATHEROSCLEROSIS, ELSEVIER, AMSTERDAM, NL, vol. 375, 1 June 2023 (2023-06-01), AMSTERDAM, NL , pages 21 - 29, XP093126499, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2023.05.012
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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