Title:
A METHOD FOR SCREENING COMPOUNDS HAVING THE CAPACITY TO CONTROL TUMOR CELL INVASION OR METASTASIS USING CONSTITUTIVELY ACTIVE AKT
Document Type and Number:
WIPO Patent Application WO2004086038
Kind Code:
A3
Abstract:
The present invention relates to a method for screening compounds having the capacity of controlling tumor cell invasion or metastasis, a method for inhibiting tumor cell invasion, as well as cell lines expressing constitutively active Akt.
Inventors:
LARUE LIONEL (FR)
Application Number:
PCT/EP2004/004021
Publication Date:
January 06, 2005
Filing Date:
March 26, 2004
Export Citation:
Assignee:
INST CURIE (FR)
CENTRE NAT RECH SCIENT (FR)
FOX CHASE CANCER CT (US)
LARUE LIONEL (FR)
CENTRE NAT RECH SCIENT (FR)
FOX CHASE CANCER CT (US)
LARUE LIONEL (FR)
International Classes:
G01N33/50; (IPC1-7): G01N33/53; C12Q1/68
Domestic Patent References:
| WO2002083064A2 | 2002-10-24 | |||
| WO2003101373A2 | 2003-12-11 | |||
| WO2001000864A2 | 2001-01-04 |
Foreign References:
| US20020165188A1 | 2002-11-07 | |||
| US20020169126A1 | 2002-11-14 | |||
| EP1109021A1 | 2001-06-20 |
Other References:
ARBOLEDA M JANE ET AL: "Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.", CANCER RESEARCH, vol. 63, no. 1, 1 January 2003 (2003-01-01), pages 196 - 206, XP002299905, ISSN: 0008-5472
NAKANISHI KAZUAKI ET AL: "Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer", CANCER RESEARCH, vol. 62, no. 10, 15 May 2002 (2002-05-15), pages 2971 - 2975, XP002299906, ISSN: 0008-5472
PARK BAE-KEUN ET AL: "Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells", CANCER RESEARCH, vol. 61, no. 20, 15 October 2001 (2001-10-15), pages 7647 - 7653, XP002299907, ISSN: 0008-5472
MENDE INES ET AL: "Oncogenic transformation induced by membrane-targeted Akt2 and Akt3", ONCOGENE, vol. 20, no. 32, 19 July 2001 (2001-07-19), pages 4419 - 4423, XP002299908, ISSN: 0950-9232
POSER INA ET AL: "Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 27, 6 July 2001 (2001-07-06), pages 24661 - 24666, XP002299909, ISSN: 0021-9258
TESTA JOSEPH R ET AL: "AKT plays a central role in tumorigenesis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 20, 25 September 2001 (2001-09-25), pages 10983 - 10985, XP002299910, ISSN: 0027-8424
GRILLE SYLVIA JULIEN ET AL: "The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.", CANCER RESEARCH, vol. 63, no. 9, 1 May 2003 (2003-05-01), pages 2172 - 2178, XP002299913, ISSN: 0008-5472
NAKANISHI KAZUAKI ET AL: "Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer", CANCER RESEARCH, vol. 62, no. 10, 15 May 2002 (2002-05-15), pages 2971 - 2975, XP002299906, ISSN: 0008-5472
PARK BAE-KEUN ET AL: "Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells", CANCER RESEARCH, vol. 61, no. 20, 15 October 2001 (2001-10-15), pages 7647 - 7653, XP002299907, ISSN: 0008-5472
MENDE INES ET AL: "Oncogenic transformation induced by membrane-targeted Akt2 and Akt3", ONCOGENE, vol. 20, no. 32, 19 July 2001 (2001-07-19), pages 4419 - 4423, XP002299908, ISSN: 0950-9232
POSER INA ET AL: "Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 27, 6 July 2001 (2001-07-06), pages 24661 - 24666, XP002299909, ISSN: 0021-9258
TESTA JOSEPH R ET AL: "AKT plays a central role in tumorigenesis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 20, 25 September 2001 (2001-09-25), pages 10983 - 10985, XP002299910, ISSN: 0027-8424
GRILLE SYLVIA JULIEN ET AL: "The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.", CANCER RESEARCH, vol. 63, no. 9, 1 May 2003 (2003-05-01), pages 2172 - 2178, XP002299913, ISSN: 0008-5472
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