Title:
METHOD OF SCREENING DRUG WITH THE USE OF 67 kDa LAMININ RECEPTOR AND DRUG OBTAINED THEREBY
Document Type and Number:
WIPO Patent Application WO/2004/090541
Kind Code:
A1
Abstract:
It is intended to provide a novel method of screening a drug with the use of a 67 kDa laminin receptor and a drug obtained thereby. A method of screening a drug having an effect of inhibiting cell proliferation, an angiogenesis inhibitory effect, an effect of inhibiting cancer cell metastasis, a nerve protecting effect, an antiallergic effect, an antiareteriosclerotic effect and/or an effect of inhibiting infection with Creutzfeldt-Jakob disease which involves the step of qualitatively or quantitatively measuring the degree of the binding of a test compound to a 67 kDa laminin receptor, and judging that the test compound is a drug having an effect of inhibiting cell proliferation, an angiogenesis inhibitory effect, an effect of inhibiting cancer cell metastasis, a nerve protecting effect, an antiallergic effect, an antiareteriosclerotic effect and/or an effect of inhibiting infection with Creutzfeldt-Jakob disease in the case where it is found out by the results of the measurement that the test compound binds to the 67 kDa laminin receptor, and a drug obtained thereby.
Inventors:
TACHIBANA HIROFUMI (JP)
Application Number:
PCT/JP2004/004772
Publication Date:
October 21, 2004
Filing Date:
April 01, 2004
Export Citation:
Assignee:
MITSUBISHI PHARMA CORP (JP)
TACHIBANA HIROFUMI (JP)
TACHIBANA HIROFUMI (JP)
International Classes:
A61K31/353; A61P9/00; A61P9/10; A61P25/00; A61P25/28; A61P35/00; A61P37/08; C07K14/705; G01N33/68; (IPC1-7): G01N33/53; G01N33/50; G01N33/15; A61K45/00; A61K31/353; A61P9/00; A61P9/10; A61P25/00; A61P25/28; A61P35/00; A61P37/08
Domestic Patent References:
| WO1999054356A1 | 1999-10-28 |
Foreign References:
| JP2000226329A | 2000-08-15 | |||
| JP2002220340A | 2002-08-09 | |||
| JP2001114687A | 2001-04-24 | |||
| JPH08205885A | 1996-08-13 | |||
| JPH06219965A | 1994-08-09 |
Other References:
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T. H. LANDOWSKI, BIOCHEMISTRY, vol. 34, 1995, pages 11276 - 11287
S. BUTO, J. CELL. BIOCHEM., vol. 69, 1998, pages 244 - 251
Y. SHI, CELL. MOL. LIFE SCI., vol. 59, 2002, pages 1577 - 1583
H. COGGIN, JR., ANTICANCER RESEARCH, vol. 19, 1999, pages 5535 - 5542
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S. MENARD ET AL., CLINICAL CANCER RESEARCH, vol. 3, 1997, pages 227 - 231
G. FONTANINI ET AL., CLINICAL CANCER RESEARCH, vol. 2, 1996, pages 1777 - 1780
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S. MENARD, BREAST CANCER RESEARCH AND TREATMENT, vol. 52, 1998, pages 137 - 145
K. SATOH, BRITISH JOURNAL OF CANCER, vol. 80, 1999, pages 1115 - 1122
M. TANAKA, CANCER LETTERS, vol. 153, 2000, pages 161 - 168
K. NARUMI, JPN. J. CANCER RES., vol. 90, 1999, pages 425 - 431
D. GEBAROWSKA, AM. J. PATHOL., vol. 160, 2002, pages 307 - 313
T. GLOE, J. BIOL. CHEM., vol. 274, 1999, pages 15996 - 16002
S. GAUCZYNSKI, EMBO J., vol. 20, 2001, pages 5863 - 5875
S. M. CANFIELD, J. IMMUNOL., vol. 163, 1999, pages 3430 - 3440
N. CLAUSSE, BIOCHEM. BIOPHYS. RES. COMMUN., vol. 251, 1998, pages 564 - 569
A. BRADFIELD ET AL., J. CHEM. SOC., vol. 32, 1947, pages 2249
KEIICHIRO MURAMATSU: "Functions of Tea", 2002, SOCIETY PUBLISHING CENTER
D. M. SMITH, INT. J. MOL. MED., vol. 7, 2001, pages 645 - 652
K. T. KAVANAGH, J. CELL. BIOCHEM., vol. 82, 2001, pages 387 - 398
N. AHMAD, ARCH. BIOCHEM. BIOPHYS., vol. 376, 2000, pages 338 - 346
M. SUSUKA, CANCER LETT., vol. 98, 1995, pages 27 - 31
M. ISEMURA, CELL BIOL. INT., vol. 17, 1993, pages 559 - 564
Y. SUZUKI, CANCER LETT., vol. 173, 2001, pages 15 - 20
S. PIANETTI, CANCER RES., vol. 62, 2002, pages 652 - 655
S. LAMY, CANCER RES., vol. 62, 2002, pages 381 - 385
A. SACHINIDIS, FASEB J., vol. 16, 2002, pages 893 - 895
Y. CAO, NATURE, vol. 389, 1999, pages 381
S. HAYAKAWA, BIOCHEM. BIOPHYS. RES. COMMUN., vol. 285, 2001, pages 1102 - 1106
M. E. WALTNER-LAW, J. BIOL. CHEM., vol. 277, 2002, pages 34933 - 34940
Y. LEVITES, J. BIOL. CHEM., vol. 277, 2002, pages 30574 - 30580
Y. FUJIMURA, J. AGRIC. FOOD CHEM., vol. 50, 2002, pages 5729 - 5734
S. AHMED, FREE RADICAL BIOLOGY & MEDICINE, vol. 33, 2002, pages 1097 - 2002
BIOCHEMISTRY, vol. 34, 1995, pages 11276 - 11287
J. CELL. BIOCHEM., vol. 69, 1998, pages 244 - 251
CELL. MOL. LIFE SCI., vol. 59, 2002, pages 1577 - 1583
ANTICANCER RESEARCH, vol. 19, 1999, pages 5535 - 5542
CLINICAL CANCER RESEARCH, vol. 3, 1997, pages 227 - 231
CLINICAL CANCER RESEARCH, vol. 2, 1996, pages 1777 - 1780
J. NATL. CANCER INST., vol. 83, 1991, pages 29 - 36
BRITISH JOURNAL OF CANCER, vol. 80, 1999, pages 1115 - 1122
CANCER LETTERS, vol. 153, 2000, pages 161 - 168
JPN. J. CANCER RES., vol. 90, 1999, pages 425 - 431
AM. J. PATHOL., vol. 160, 2002, pages 307 - 313
J. BIOL. CHEM., vol. 274, 1999, pages 15996 - 16002
EMBO J., vol. 20, 2001, pages 5863 - 5875
J. IMMUNOL., vol. 163, 1999, pages 3430 - 3440
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 251, 1998, pages 564 - 569
J. CHEM. SOC., vol. 32, 1947, pages 2249
INT. J. MOL. MED., vol. 7, 2001, pages 645 - 652
J. CELL. BIOCHEM., vol. 82, 2001, pages 387 - 398
ARCH. BIOCHEM. BIOPHYS., vol. 376, 2000, pages 338 - 346
CANCER LETT., vol. 98, 1995, pages 27 - 31
CELL. BIOL. INT., vol. 17, 1993, pages 559 - 564
CANCER LETT., vol. 173, 2001, pages 15 - 20
CANCER RES., vol. 62, 2002, pages 652 - 655
CANCER RES., vol. 62, 2002, pages 381 - 385
FASEB J., vol. 16, 2002, pages 893 - 895
NATURE, vol. 389, 1999, pages 381
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 285, 2001, pages 1102 - 1106
J. BIOL. CHEM., vol. 277, 2002, pages 34933 - 34940
J. BIOL. CHEM., vol. 277, 2002, pages 30574 - 30580
J. AGRIC. FOOD CHEM., vol. 50, 2002, pages 5729 - 5734
FREE RADICAL BIOLOGY & MEDICINE, vol. 33, 2002, pages 1097 - 2002
H. YOU, PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 6394
YOW ET AL., PROC. NATL. ACAD. SCI. USA., vol. 85, 1988, pages 6394 - 6398
T. H. LANDOWSKI, BIOCHEMISTRY, vol. 34, 1995, pages 11276 - 11287
S. BUTO, J. CELL. BIOCHEM., vol. 69, 1998, pages 244 - 251
Y. SHI, CELL. MOL. LIFE SCI., vol. 59, 2002, pages 1577 - 1583
H. COGGIN, JR., ANTICANCER RESEARCH, vol. 19, 1999, pages 5535 - 5542
BREAST CANCER RESEARCH AND TREATMENT, vol. 52, 1998, pages 137 - 145
S. MENARD ET AL., CLINICAL CANCER RESEARCH, vol. 3, 1997, pages 227 - 231
G. FONTANINI ET AL., CLINICAL CANCER RESEARCH, vol. 2, 1996, pages 1777 - 1780
F. BASOLO; V. COICE ET AL., J. NATL. CANCER INST., vol. 83, 1991, pages 29 - 36
S. MENARD, BREAST CANCER RESEARCH AND TREATMENT, vol. 52, 1998, pages 137 - 145
K. SATOH, BRITISH JOURNAL OF CANCER, vol. 80, 1999, pages 1115 - 1122
M. TANAKA, CANCER LETTERS, vol. 153, 2000, pages 161 - 168
K. NARUMI, JPN. J. CANCER RES., vol. 90, 1999, pages 425 - 431
D. GEBAROWSKA, AM. J. PATHOL., vol. 160, 2002, pages 307 - 313
T. GLOE, J. BIOL. CHEM., vol. 274, 1999, pages 15996 - 16002
S. GAUCZYNSKI, EMBO J., vol. 20, 2001, pages 5863 - 5875
S. M. CANFIELD, J. IMMUNOL., vol. 163, 1999, pages 3430 - 3440
N. CLAUSSE, BIOCHEM. BIOPHYS. RES. COMMUN., vol. 251, 1998, pages 564 - 569
A. BRADFIELD ET AL., J. CHEM. SOC., vol. 32, 1947, pages 2249
KEIICHIRO MURAMATSU: "Functions of Tea", 2002, SOCIETY PUBLISHING CENTER
D. M. SMITH, INT. J. MOL. MED., vol. 7, 2001, pages 645 - 652
K. T. KAVANAGH, J. CELL. BIOCHEM., vol. 82, 2001, pages 387 - 398
N. AHMAD, ARCH. BIOCHEM. BIOPHYS., vol. 376, 2000, pages 338 - 346
M. SUSUKA, CANCER LETT., vol. 98, 1995, pages 27 - 31
M. ISEMURA, CELL BIOL. INT., vol. 17, 1993, pages 559 - 564
Y. SUZUKI, CANCER LETT., vol. 173, 2001, pages 15 - 20
S. PIANETTI, CANCER RES., vol. 62, 2002, pages 652 - 655
S. LAMY, CANCER RES., vol. 62, 2002, pages 381 - 385
A. SACHINIDIS, FASEB J., vol. 16, 2002, pages 893 - 895
Y. CAO, NATURE, vol. 389, 1999, pages 381
S. HAYAKAWA, BIOCHEM. BIOPHYS. RES. COMMUN., vol. 285, 2001, pages 1102 - 1106
M. E. WALTNER-LAW, J. BIOL. CHEM., vol. 277, 2002, pages 34933 - 34940
Y. LEVITES, J. BIOL. CHEM., vol. 277, 2002, pages 30574 - 30580
Y. FUJIMURA, J. AGRIC. FOOD CHEM., vol. 50, 2002, pages 5729 - 5734
S. AHMED, FREE RADICAL BIOLOGY & MEDICINE, vol. 33, 2002, pages 1097 - 2002
BIOCHEMISTRY, vol. 34, 1995, pages 11276 - 11287
J. CELL. BIOCHEM., vol. 69, 1998, pages 244 - 251
CELL. MOL. LIFE SCI., vol. 59, 2002, pages 1577 - 1583
ANTICANCER RESEARCH, vol. 19, 1999, pages 5535 - 5542
CLINICAL CANCER RESEARCH, vol. 3, 1997, pages 227 - 231
CLINICAL CANCER RESEARCH, vol. 2, 1996, pages 1777 - 1780
J. NATL. CANCER INST., vol. 83, 1991, pages 29 - 36
BRITISH JOURNAL OF CANCER, vol. 80, 1999, pages 1115 - 1122
CANCER LETTERS, vol. 153, 2000, pages 161 - 168
JPN. J. CANCER RES., vol. 90, 1999, pages 425 - 431
AM. J. PATHOL., vol. 160, 2002, pages 307 - 313
J. BIOL. CHEM., vol. 274, 1999, pages 15996 - 16002
EMBO J., vol. 20, 2001, pages 5863 - 5875
J. IMMUNOL., vol. 163, 1999, pages 3430 - 3440
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 251, 1998, pages 564 - 569
J. CHEM. SOC., vol. 32, 1947, pages 2249
INT. J. MOL. MED., vol. 7, 2001, pages 645 - 652
J. CELL. BIOCHEM., vol. 82, 2001, pages 387 - 398
ARCH. BIOCHEM. BIOPHYS., vol. 376, 2000, pages 338 - 346
CANCER LETT., vol. 98, 1995, pages 27 - 31
CELL. BIOL. INT., vol. 17, 1993, pages 559 - 564
CANCER LETT., vol. 173, 2001, pages 15 - 20
CANCER RES., vol. 62, 2002, pages 652 - 655
CANCER RES., vol. 62, 2002, pages 381 - 385
FASEB J., vol. 16, 2002, pages 893 - 895
NATURE, vol. 389, 1999, pages 381
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 285, 2001, pages 1102 - 1106
J. BIOL. CHEM., vol. 277, 2002, pages 34933 - 34940
J. BIOL. CHEM., vol. 277, 2002, pages 30574 - 30580
J. AGRIC. FOOD CHEM., vol. 50, 2002, pages 5729 - 5734
FREE RADICAL BIOLOGY & MEDICINE, vol. 33, 2002, pages 1097 - 2002
H. YOU, PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 6394
YOW ET AL., PROC. NATL. ACAD. SCI. USA., vol. 85, 1988, pages 6394 - 6398
Attorney, Agent or Firm:
Takayanagi, Masau (Intellectual Property Department 2-6,
Nihonbashi-honcho 2-chom, Chuo-ku Tokyo 05, JP)
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