Title:
METHOD OF SCREENING DRUG
Document Type and Number:
WIPO Patent Application WO/2003/052408
Kind Code:
A1
Abstract:
A method of screening a drug which inhibits at least one phenomenon selected from among microbial metabolism, growth and infection, characterized in that a substance serving as a ligand of an Lrp−like protein is selected based on the stereostructural data of the protein.
Inventors:
SUZUKI MASASHI (JP)
KOIKE HIDEAKI (JP)
KOIKE HIDEAKI (JP)
Application Number:
PCT/JP2002/013193
Publication Date:
June 26, 2003
Filing Date:
December 17, 2002
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
JAPAN SCIENCE & TECH CORP (JP)
SUZUKI MASASHI (JP)
KOIKE HIDEAKI (JP)
JAPAN SCIENCE & TECH CORP (JP)
SUZUKI MASASHI (JP)
KOIKE HIDEAKI (JP)
International Classes:
A61K45/00; A61P31/04; C12N15/09; G01N23/20; C12Q1/18; C12Q1/68; G01N33/15; G01N33/48; G01N33/50; G01N33/68; G06F17/30; (IPC1-7): G01N33/15; G01N33/50
Other References:
LEONARD PHILIP M. ET AL.: "Crystal structure of the Lrp-like transcriptional regulator from the archaeon pyrococcus furiosus", THE EMBO JOURNAL, vol. 20, no. 5, March 2001 (2001-03-01), pages 990 - 997, XP002962914
CHEN SHAOLIN ET AL.: "Leucine-induced dissociation of escherichia coli Lrp hexadecamers to octamers", JOURNAL OF MOLECULAR BIOLOGY, vol. 318, no. 4, May 2002 (2002-05-01), pages 1031 - 1042, XP002962915
CHEN SHAOLIN ET AL.: "Leucine-induced dissociation of escherichia coli Lrp hexadecamers to octamers", JOURNAL OF MOLECULAR BIOLOGY, vol. 318, no. 4, May 2002 (2002-05-01), pages 1031 - 1042, XP002962915
Attorney, Agent or Firm:
Hiraki, Yusuke (17-1 Toranomon 1-chom, Minato-ku Tokyo, JP)
Download PDF: