Title:
METHOD FOR SCREENING FOR FEED WHICH ENABLES PRODUCTION OF MILK HAVING IMMUNOMODULATING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2012/096272
Kind Code:
A1
Abstract:
A feed or substance which enables the production of breast milk having an immunomodulating activity can be screened by identifying a feed or substance capable of increasing or decreasing the abundance of mRNA in milk, wherein the identification is performed employing the correlation between the mRNA profile in milk of a mammal and a feed ingested by the mammal or a substance contained in the feed as a measure.
Inventors:
IZUMI HIROHISA (JP)
SHIMIZU TAKASHI (JP)
SEKINE KAZUNORI (JP)
SHIMIZU TAKASHI (JP)
SEKINE KAZUNORI (JP)
Application Number:
PCT/JP2012/050312
Publication Date:
July 19, 2012
Filing Date:
January 11, 2012
Export Citation:
Assignee:
MORINAGA MILK INDUSTRY CO LTD (JP)
IZUMI HIROHISA (JP)
SHIMIZU TAKASHI (JP)
SEKINE KAZUNORI (JP)
IZUMI HIROHISA (JP)
SHIMIZU TAKASHI (JP)
SEKINE KAZUNORI (JP)
International Classes:
C12Q1/68; A23C9/152; A23L33/00
Foreign References:
| JP2003199598A | 2003-07-15 |
Other References:
ADMYRE CHARLOTTE ET AL.: "Exosomes with Immune Modulatory Features Are Present in Human Breast Milk", J. IMMUNOL., vol. 179, 2007, pages 1969 - 1978, XP055113095
VALADI HADI ET AL.: "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells", NATURE CELL BIOLOGY, vol. 9, no. 6, 2007, pages 654 - 659, XP003016816
HATA TAKETOSHI ET AL.: "Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 396, 2010, pages 528 - 533, XP055113144
CLINTON CATHERINE: "Development of the infant Immune Function and the Effects of Breast Milk", NATURAL MEDICINE JOURNAL, vol. 2, no. 8, 2010, pages 3 - 6, XP055113156
HIROHISA IZUMI ET AL.: "Boshikan o Ido suru Bonyuchu Exosome no Igi", EXPERIMENTAL MEDICINE, vol. 29, no. 3, February 2011 (2011-02-01), pages 399 - 403, XP008171074
KOSAKA NOBUYOSHI ET AL.: "MicroRNA as a new immune-regulatory agent in breast milk", SILENCE, vol. 1, 2010, pages 7, XP021070612
SIMPSON R.J., EXPERT REV. PROTEOMICS, vol. 6, 2009, pages 267 - 283
CHEN, X. ET AL., CELL RES., vol. 20, 2010, pages 1128 - 1137
WEBER, J.A. ET AL., CLIN. CHEM., vol. 56, 2010, pages 1733 - 1741
KOSAKA, N. ET AL., SILENCE, vol. 1, 2010, pages 7
HATA, T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 396, 2010, pages 528 - 533
PALANISAMY, V. ET AL., PLOS ONE, vol. 3, no. 9, 2008, pages E3148
MIRANDA. K.C. ET AL., KIDNEY INT., vol. 78, 2010, pages 191 - 199
GOLDMAN, A.S., BREASTFEED. MED., vol. 2, no. 4, 2007, pages 195 - 204
BREASTFEED MED., vol. 2, no. 4, 2007, pages 195 - 204
THE JOURNAL OF NUTRITION, vol. 140, no. 3, 27 January 2010 (2010-01-27), pages 698S - 712S
LABOR; WELFARE, JAPANESE MINISTRY OF HEALTH, 30 April 2003 (2003-04-30)
TAKAHASHI, N. ET AL., CLIN. EXP. IMMUNOL., vol. 145, 2006, pages 130 - 138
See also references of EP 2664676A4
VALADI HADI ET AL.: "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells", NATURE CELL BIOLOGY, vol. 9, no. 6, 2007, pages 654 - 659, XP003016816
HATA TAKETOSHI ET AL.: "Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 396, 2010, pages 528 - 533, XP055113144
CLINTON CATHERINE: "Development of the infant Immune Function and the Effects of Breast Milk", NATURAL MEDICINE JOURNAL, vol. 2, no. 8, 2010, pages 3 - 6, XP055113156
HIROHISA IZUMI ET AL.: "Boshikan o Ido suru Bonyuchu Exosome no Igi", EXPERIMENTAL MEDICINE, vol. 29, no. 3, February 2011 (2011-02-01), pages 399 - 403, XP008171074
KOSAKA NOBUYOSHI ET AL.: "MicroRNA as a new immune-regulatory agent in breast milk", SILENCE, vol. 1, 2010, pages 7, XP021070612
SIMPSON R.J., EXPERT REV. PROTEOMICS, vol. 6, 2009, pages 267 - 283
CHEN, X. ET AL., CELL RES., vol. 20, 2010, pages 1128 - 1137
WEBER, J.A. ET AL., CLIN. CHEM., vol. 56, 2010, pages 1733 - 1741
KOSAKA, N. ET AL., SILENCE, vol. 1, 2010, pages 7
HATA, T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 396, 2010, pages 528 - 533
PALANISAMY, V. ET AL., PLOS ONE, vol. 3, no. 9, 2008, pages E3148
MIRANDA. K.C. ET AL., KIDNEY INT., vol. 78, 2010, pages 191 - 199
GOLDMAN, A.S., BREASTFEED. MED., vol. 2, no. 4, 2007, pages 195 - 204
BREASTFEED MED., vol. 2, no. 4, 2007, pages 195 - 204
THE JOURNAL OF NUTRITION, vol. 140, no. 3, 27 January 2010 (2010-01-27), pages 698S - 712S
LABOR; WELFARE, JAPANESE MINISTRY OF HEALTH, 30 April 2003 (2003-04-30)
TAKAHASHI, N. ET AL., CLIN. EXP. IMMUNOL., vol. 145, 2006, pages 130 - 138
See also references of EP 2664676A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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