Title:
METHOD FOR SCREENING FOR, METHOD FOR PRODUCING, AND METHOD FOR DESIGNING DRUG ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2021/201170
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel screening technology for selecting useful drug compounds. The present invention, which solves the problem, is a method for screening for drug active ingredients, comprising the following step A, step B and/or step C, and step D. Step A is a step for administering a candidate substance to an animal (excluding humans), step B is a step for observing undifferentiated cells in the animal previously subjected to step A, step C is a step for observing differentiated cells in the animal previously subjected to step A, and step D is a step for selecting, in comparison to the case in which the candidate substance is not administered, the following as an active ingredient: a candidate substance that increases the amount of the undifferentiated cells, or a candidate substance that increases the amount of the differentiated cells or increases the function of tissue composed of the differentiated cells.
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Inventors:
ANDO HIDEKI (JP)
Application Number:
PCT/JP2021/014027
Publication Date:
October 07, 2021
Filing Date:
March 31, 2021
Export Citation:
Assignee:
SKY PHARMA CO LTD (JP)
International Classes:
A61K45/00; A61K9/06; A61K9/08; A61K9/19; A61K31/167; A61K31/198; A61K31/44; A61K31/4709; A61K31/506; A61K31/519; A61K31/675; A61P25/00; A61P27/02; A61P27/06; A61P43/00; C12N15/12; C12N15/62; C12Q1/06; C12Q1/6841; C12Q1/6897; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| WO2016002854A1 | 2016-01-07 | |||
| WO2012124752A1 | 2012-09-20 | |||
| WO2013035824A1 | 2013-03-14 | |||
| WO1993019166A1 | 1993-09-30 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO2016002854A1 | 2016-01-07 | |||
| WO2015127351A1 | 2015-08-27 |
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| JP2010500039A | 2010-01-07 | |||
| JP2013046597A | 2013-03-07 | |||
| JP2007217347A | 2007-08-30 | |||
| JP2008540340A | 2008-11-20 | |||
| JP2013220090A | 2013-10-28 | |||
| JP2008253274A | 2008-10-23 | |||
| JP2018162974A | 2018-10-18 | |||
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HAMAMOTO, KOHEI: "Emerging therapeutic strategies, Regenerative medicine for diabetes -Current status and future-", SAISHIN IGAKU. MODERN MEDICINE, vol. 62, no. 4, 10 April 2007 (2007-04-10), JP , pages 949 - 956, XP009539810, ISSN: 0370-8241
TANAKA, AKIKO: "Investigate current drug discovery research in academia <
KAZUYA KITAMURA, NARIHITO NAGOSHI, OSAHIKO TSUJI, MORIO MATSUMOTO, HIDEYUKI OKANO, MASAYA NAKAMURA: "Intrathecal administration of hepatocyte growth factor — novel strategy for acute spinal cord injury", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 271, no. 7, 16 November 2019 (2019-11-16), JP , pages 635 - 641, XP009539775, ISSN: 0039-2359
KOHSAKA, SHINICHI: "Developmental research to activation of a neural stem cell present in a living human brain", RESEARCH REPORT ON GENERALIZATION AND ALLOTMENT, 2007, pages 1 - 3, XP009543969
KITAMURA KAZUYA, FUJIYOSHI KANEHIRO, YAMANE JUN-ICHI, TOYOTA FUMIKA, HIKISHIMA KEIGO, NOMURA TATSUJI, FUNAKOSHI HIROSHI, NAKAMURA : "Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury", PLOS ONE, vol. 6, no. 11, 29 November 2011 (2011-11-29), XP055924223, DOI: 10.1371/journal.pone.0027706
KANEKIYO, KENJI: "Microenvironmental changes of spinal cord by traumatic injury and nerve regeneration", 38TH ANNUAL MEETING OF JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH; NAGOYA, JAPAN; AUGUST 19-21, 2019, vol. 38, 26 July 2019 (2019-07-26) - 21 August 2019 (2019-08-21), pages 82 - 83, XP009540123
SAFWAT A, SABRY D, RAGIAE A, AMER E, MAHMOUD RH, SHAMARDAN RM: "Adipose mesenchymal stem cells–derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits", JOURNAL OF CIRCULATING BIOMARKERS, vol. 7, 1 January 2018 (2018-01-01), XP055924227, ISSN: 1849-4544, DOI: 10.1177/1849454418807827
OOTO SOTARO, AKAGI TADAMICHI, KAGEYAMA RYOICHIRO, AKITA JOE, MANDAI MICHIKO, HONDA YOSHIHITO, TAKAHASHI MASAYO: "Potential for neural regeneration after neurotoxic injury in the adult mammalian retina", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 101, no. 37, 14 September 2004 (2004-09-14), pages 13654 - 13659, XP055924233, ISSN: 0027-8424, DOI: 10.1073/pnas.0402129101
HARADA TAKAYUKI, HARADA CHIKAKO, NAKAMURA KAZUAKI, QUAH HUN-MENG A., OKUMURA AKINORI, NAMEKATA KAZUHIKO, SAEKI TADASHIRO, AIHARA M: "The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma", THE JOURNAL OF CLINICAL INVESTIGATION, B M J GROUP, GB, vol. 117, no. 7, 2 July 2007 (2007-07-02), GB , pages 1763 - 1770, XP055924241, ISSN: 0021-9738, DOI: 10.1172/JCI30178
GRANDPRE T, LI S, STRITTMATTER S M: "Nogo-66 receptor antagonist peptide promotes axonal regeneration", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 417, 30 May 2002 (2002-05-30), London, pages 547 - 551, XP002963387, ISSN: 0028-0836, DOI: 10.1038/417547a
TAKAHASHI, NORIKO: "Induction of Cell Differentiation and Development of New Anticancer Drugs", YAKUGAKU ZASSHI, 1. INTRODUCTION, vol. 122, no. 8, 2002, pages 547 - 563, XP055969159
ANN N Y ACAD SCI, vol. 1462, no. 1, February 2020 (2020-02-01), pages 27 - 36
OXID MED CELL LONGEV, vol. 2019, 2019, pages 5813147
NATURE GENETICS, vol. 43, 2011, pages 34 - 41
BIOMED RES INT, vol. 2015, 2015, pages 727542
NEW ENGLAND JOURNAL OF MEDICINE, vol. 376, 2017, pages 1038 - 1046
THE JOURNAL OF THE JAPANESE SOCIETY FOR CATARACT RESEARCH, vol. 27, no. 1, 2015, pages 32 - 34
REGENERATIVE THERAPY: JOURNAL OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, vol. 14, no. 4, 2015, pages 319 - 329
NATURE, vol. 403, 2000, pages 439
CELL, vol. 75, 1993, pages 1389
MARINE BIOTECHNOLOGY, vol. 8, no. 3, 2006, pages 295 - 303
J NEUROCHEM, vol. 76, no. 1, January 2001 (2001-01-01), pages 173 - 81
J CANCER RES, vol. 23, no. 2, June 2011 (2011-06-01), pages 140 - 146
PLOS ONE, vol. 9, October 2014 (2014-10-01), pages e109588
ENDOCRINE REVIEWS, vol. 28, no. 3, pages 339 - 63
DEVELOPMENT, vol. 143, no. 10, 2016, pages 3050 - 3060
NEURON, vol. 40, no. 6, pages 1105 - 18
SEMIN CELL DEV BIOL, vol. 23, no. 4, June 2012 (2012-06-01), pages 473 - 480
INFLAMMATION AND REGENERATION, vol. 22, 3 May 2002 (2002-05-03), pages 195 - 200
SCI SIGNAL, vol. 2, no. 55, 27 January 2009 (2009-01-27), pages ra1
DEVELOPMENT, vol. 146, 2019, pages dev167643
STEM CELLS INT, vol. 2017, 2017, pages 1610691
CELL RESEARCH, vol. 18, 2008, pages 523 - 527
J CLIN INVEST, vol. 128, no. 9, 2018, pages 3872 - 3886
PROC NATL ACAD SCI USA, vol. 102, no. 17, 26 April 2005 (2005-04-26), pages 6068 - 73
CANCER CELL, vol. 30, 2016, pages 792 - 805
DEVELOPMENT, vol. 133, no. 21, December 2006 (2006-12-01), pages 4293 - 303
DEVELOPMENT, vol. 130, no. 18, September 2003 (2003-09-01), pages 4307 - 23
DEVELOPMENTAL DYNAMICS, vol. 238, no. 2, February 2009 (2009-02-01), pages 475 - 86
THE JOURNAL OF COMPARATIVE NEUROLOGY, vol. 469, February 2004 (2004-02-01), pages 311 - 324
DEVELOPMENTAL BIOLOGY, vol. 227, 2000, pages 279 - 293
DYNAMICS, vol. 238, no. 2, February 2009 (2009-02-01), pages 475 - 86
ILLUM L., EUR. J. PHARM. SCI., vol. 11, 2000, pages 1 - 18
FREY W.H., DRUG DELIV. TECHNOL., vol. 2, 2002, pages 46 - 49
LOCHHEAD J.J.THORNE G., ADV. DRUG DELIV. REV., vol. 64, 2012, pages 614 - 628
DJUPESLAND P.G.MESSINA J.C.MAHMOUD R.A., THER. DELIV., vol. 5, 2014, pages 709 - 733
Attorney, Agent or Firm:
TSUJITA, Tomoko et al. (JP)
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