Title:
METHOD FOR SCREENING OF SUBSTANCE CAPABLE OF PROMOTING RECOVERY OF SKIN BARRIER FUNCTION
Document Type and Number:
WIPO Patent Application WO/2011/068221
Kind Code:
A1
Abstract:
A method for screening for a substance capable of promoting the recovery of a skin barrier function, the method comprising the steps of: incubating caspase-14 and prosaposin in the presence of a candidate substance for the substance capable of promoting the recovery of a skin barrier function; and selecting the candidate substance as the substance capable of promoting the recovery of a skin barrier function when the decomposition of prosaposin into saposin A is promoted significantly compared with that achieved in the presence of a reference substance.
Inventors:
HIBINO TOSHIHIKO (JP)
YAMAMOTO MAMI (JP)
YAMAMOTO MAMI (JP)
Application Number:
PCT/JP2010/071736
Publication Date:
June 09, 2011
Filing Date:
December 03, 2010
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
HIBINO TOSHIHIKO (JP)
YAMAMOTO MAMI (JP)
HIBINO TOSHIHIKO (JP)
YAMAMOTO MAMI (JP)
International Classes:
C12Q1/37; A61K8/96; A61Q19/00; G01N33/50; G01N33/53
Other References:
TOSHIHIKO HIBINO ET AL.: "Caspase-14 no Aratana Kino - Kakusokan Shishitsu Gosei eno Kan'yo", DAI 66 KAI SCCJ KENKYU TORONKAI KOEN YOSHISHU, 30 June 2010 (2010-06-30), pages 27 - 28, XP008163832
M YAMAMOTO ET AL.: "Caspase-14 participates in the processing of prosaposin during the terminal differentiation", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 130, April 2010 (2010-04-01), pages S78, XP008163838
GEERTRUI DENECKER ET AL.: "Caspase-14 reveals its secrets", THE JOURNAL OF CELL BIOLOGY, vol. 180, no. 3, 2008, pages 451 - 458, XP009137804
DOUGLAS S. WALSH ET AL.: "Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 37, 2005, pages 61 - 63, XP004689814
HEINZ FISCHER ET AL.: "Stratum corneum-derived caspase-14 is catalytically active", FEBS LETTERS, vol. 577, 2004, pages 446 - 450, XP004647178
KLAUS HARZER ET AL.: "Saposins (sap) A and C activate the degradation of galactosylsphingosine", FEBS LETTERS, vol. 508, 2001, pages 107 - 110, XP004322287
See also references of EP 2508616A4
TEZUKA ET AL., JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 109, 1997, pages 319 - 323
ALESSANDRINI ET AL., JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 116, 2001, pages 394 - 400
MIKOLAJCZYK J. ET AL., BIOCHEMISTRY, vol. 43, 2004, pages 10560 - 9
LIPPENS S. ET AL., CELL DEATH DIFFER., vol. 7, 2000, pages 1218 - 24
M YAMAMOTO ET AL.: "Caspase-14 participates in the processing of prosaposin during the terminal differentiation", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 130, April 2010 (2010-04-01), pages S78, XP008163838
GEERTRUI DENECKER ET AL.: "Caspase-14 reveals its secrets", THE JOURNAL OF CELL BIOLOGY, vol. 180, no. 3, 2008, pages 451 - 458, XP009137804
DOUGLAS S. WALSH ET AL.: "Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 37, 2005, pages 61 - 63, XP004689814
HEINZ FISCHER ET AL.: "Stratum corneum-derived caspase-14 is catalytically active", FEBS LETTERS, vol. 577, 2004, pages 446 - 450, XP004647178
KLAUS HARZER ET AL.: "Saposins (sap) A and C activate the degradation of galactosylsphingosine", FEBS LETTERS, vol. 508, 2001, pages 107 - 110, XP004322287
See also references of EP 2508616A4
TEZUKA ET AL., JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 109, 1997, pages 319 - 323
ALESSANDRINI ET AL., JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 116, 2001, pages 394 - 400
MIKOLAJCZYK J. ET AL., BIOCHEMISTRY, vol. 43, 2004, pages 10560 - 9
LIPPENS S. ET AL., CELL DEATH DIFFER., vol. 7, 2000, pages 1218 - 24
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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