Title:
METHOD FOR STABILIZATION OF ISOXAZOLE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2007/046411
Kind Code:
A1
Abstract:
3-[(1S)-1-(2-fluorobiphenyl-4-yl)ethyl]-5-[[amino(morpholin-4-yl)methylene]amino]isoxazole is an isoxazole compound useful as a therapeutic agent for an autoimmune disease. The isoxazole compound can be stabilized by using an antioxidant such as a pyrosulfurous acid salt, a bisulfite salt, a sulfurous acid salt or dibutylhydroxytoluene. A pharmaceutical composition for oral administration comprising the isoxazole compound and the antioxidant is an excellent pharmaceutical composition, since the isoxazole compound contained in the composition is stabilized.
Inventors:
NISHII HIROYUKI (JP)
MATSUOKA MAKOTO (JP)
MATSUOKA MAKOTO (JP)
Application Number:
PCT/JP2006/320732
Publication Date:
April 26, 2007
Filing Date:
October 18, 2006
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
NISHII HIROYUKI (JP)
MATSUOKA MAKOTO (JP)
NISHII HIROYUKI (JP)
MATSUOKA MAKOTO (JP)
International Classes:
A61K9/16; C07D261/14; A61K9/20; A61K9/28; A61K31/5377; A61K47/02; A61K47/10; A61K47/12; A61K47/14; A61K47/16; A61K47/20; A61K47/22; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61K47/44; A61P29/00; A61P37/02
Domestic Patent References:
| WO2002092094A1 | 2002-11-21 | |||
| WO2004096230A1 | 2004-11-11 |
Foreign References:
| JPH11240873A | 1999-09-07 |
Other References:
See also references of EP 1950205A4
Attorney, Agent or Firm:
ASAMURA, Kiyoshi et al. (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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