Title:
METHOD FOR STABILIZING RAMALIN USING POROUS MATRIX, AND STABLIZED RAMALIN SOLUTION
Document Type and Number:
WIPO Patent Application WO/2013/141576
Kind Code:
A1
Abstract:
The present invention relates to a method for stabilizing ramalin and a stabilized ramalin solution, and more specifically to a method for stabilizing ramalin and a solution of thus stabilized ramalin, the method for stabilizing ramalin being characterized by adhering ramalin to a hydrophilic and porous matrix, then modifying the surface thereof so as to disperse same in an organic solvent. A method for stabilizing ramalin according to the present invention allows stabilizing ramalin in such a way as to maintain similar potency in comparison to the standard preparation of ramalin even when stored for an extended period of time, thus having the benefit of allowing an extended storage of ramalin, which has excellent antioxidant and anti-inflammatory activities. Furthermore, the method according the present invention facilitates storage of ramalin as the potency thereof is maintained even when stored for an extended period at a high temperature such as 45 °C.
Inventors:
YIM JOUNG HAN (KR)
KIM IL-CHAN (KR)
KIM DOCKYU (KR)
HAN SE JONG (KR)
LEE HYOUNG SEOK (KR)
HARI DATTA BHATTARAI (KR)
PARK SU JIN (KR)
KIM IL-CHAN (KR)
KIM DOCKYU (KR)
HAN SE JONG (KR)
LEE HYOUNG SEOK (KR)
HARI DATTA BHATTARAI (KR)
PARK SU JIN (KR)
Application Number:
PCT/KR2013/002247
Publication Date:
September 26, 2013
Filing Date:
March 19, 2013
Export Citation:
Assignee:
KOREA OCEAN RES AND DEV INSITUTE (KR)
International Classes:
C07C231/22; A61K31/165; A61Q19/08; C07C237/04
Domestic Patent References:
| WO2010053327A2 | 2010-05-14 | |||
| WO2012008785A2 | 2012-01-19 | |||
| WO2011152671A2 | 2011-12-08 |
Other References:
GULLUCE, M. ET AL.: "Screening the antioxidant and antimicrobial properties of the lichens Parmelia saxatilis, Platismatia glauca, Ramalina pollinaria, Ramalina polymorpha and Umbilicaria nylanderiana", PHYTOMEDICINE, vol. 13, 2006, pages 515 - 521, XP028022214, DOI: doi:10.1016/j.phymed.2005.09.008
BHATTARAI, H. D. ET AL.: "thin layer chromatography analysis of antioxidant constituents of lichens from Antarctica", JOURNAL OF NATURAL MEDICINES, vol. 62, 2008, pages 481 - 484, XP055157233, DOI: doi:10.1007/s11418-008-0257-9
KINOSHITA, T. ET AL.: "The synthesis of Anthglutin and its analogues", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 44, 1981, pages 2219 - 2220
BHATTARAI, H. D. ET AL.: "thin layer chromatography analysis of antioxidant constituents of lichens from Antarctica", JOURNAL OF NATURAL MEDICINES, vol. 62, 2008, pages 481 - 484, XP055157233, DOI: doi:10.1007/s11418-008-0257-9
KINOSHITA, T. ET AL.: "The synthesis of Anthglutin and its analogues", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 44, 1981, pages 2219 - 2220
Attorney, Agent or Firm:
LEE, Cheo Young (KR)
이처영 (KR)
이처영 (KR)
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