Title:
METHOD FOR STORING INTERMEDIATE FOR RADIOPHARMACEUTICAL COMPOSITION, METHOD FOR PREPARATION OR STORAGE OF RADIOPHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOSITION FOR RADIOPHARMACEUTICAL COMPOSITION, AND PHARMACEUTICAL FORMULATION
Document Type and Number:
WIPO Patent Application WO/2022/230390
Kind Code:
A1
Abstract:
The storage method according to the present invention comprises storing an intermediate for a radiopharmaceutical composition in an acetate buffer. The intermediate is a complex between an anti-epidermal growth factor receptor antibody (anti-EGFR antibody) and 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA). The storage period is at least 24 hours.
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Inventors:
YOSHII YUKIE (JP)
MATSUMOTO HIROKI (JP)
IGARASHI CHIKA (JP)
MATSUMOTO HIROKI (JP)
IGARASHI CHIKA (JP)
Application Number:
PCT/JP2022/010771
Publication Date:
November 03, 2022
Filing Date:
March 11, 2022
Export Citation:
Assignee:
NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECH (JP)
International Classes:
A61K51/04; A61K39/395; A61K47/68; A61K51/10
Foreign References:
| JP2017214308A | 2017-12-07 | |||
| JP2007512266A | 2007-05-17 |
Other References:
W. F. MAGUIRE, M. R. MCDEVITT, P. M. SMITH-JONES, D. A. SCHEINBERG: "Efficient 1-Step Radiolabeling of Monoclonal Antibodies to High Specific Activity with 225Ac for -Particle Radioimmunotherapy of Cancer", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 55, no. 9, 1 September 2014 (2014-09-01), US , pages 1492 - 1498, XP055568060, ISSN: 0161-5505, DOI: 10.2967/jnumed.114.138347
YOSHII ET AL., SCI REP, vol. 10, 2020, pages 4143
YOSHII ET AL., J NUCL MED., vol. 60, 2019, pages 1437 - 1443
YOSHII ET AL., ONCOTARGET, vol. 9, 2018, pages 28935 - 28950
SONG IH ET AL., ONCOTARGET, vol. 8, 2017, pages 92090 - 92105
SONG IH ET AL., J NUCL MED., vol. 57, 2016, pages 1105 - 11
NUCL MED BIOL, vol. 43, no. 11, pages 685 - 691
CANCER SCI, vol. 103, no. 3, pages 600 - 605
PLOS ONE, vol. 10, no. 4, pages e0123761
LINDMO ET AL., J IMMUNOL METHODS., vol. 72, 1984, pages 77 - 89
YOSHII ET AL., SCI REP, vol. 10, 2020, pages 4143
YOSHII ET AL., J NUCL MED., vol. 60, 2019, pages 1437 - 1443
YOSHII ET AL., ONCOTARGET, vol. 9, 2018, pages 28935 - 28950
SONG IH ET AL., ONCOTARGET, vol. 8, 2017, pages 92090 - 92105
SONG IH ET AL., J NUCL MED., vol. 57, 2016, pages 1105 - 11
NUCL MED BIOL, vol. 43, no. 11, pages 685 - 691
CANCER SCI, vol. 103, no. 3, pages 600 - 605
PLOS ONE, vol. 10, no. 4, pages e0123761
LINDMO ET AL., J IMMUNOL METHODS., vol. 72, 1984, pages 77 - 89
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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