Title:
METHOD FOR SYNTHESIZING 1,7-DI-(4-HYDROXYPHENYL)-HEPTANE-1,4-DIEN-3-ONE
Document Type and Number:
WIPO Patent Application WO/2019/080682
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical synthesis, and relates to a method for the synthesis of 1,7-di-(4-hydroxyphenyl)-heptane-1,4-dien-3-one. A method for synthesizing 1,7-di-(4-hydroxyphenyl)-heptane-1,4-dien-3-one uses 3-(4-hydroxyphenyl)propionic acid and 4-hydroxybenzaldehyde as raw materials, and comprises the following steps: (I) using 3-(4-hydroxyphenyl)propionic acid as a raw material, and subjecting same to esterification, methylation protection, reduction and oxidation to obtain 3-(4-(methoxymethyl)phenyl)propanal; (II) subjecting 4-hydroxybenzaldehyde to etherification and aldol condensation reaction to obtain 4-(4-(methoxymethyl)phenyl)but-3-en-2-one; and (III) performing aldol condensation reaction of 4-(4-(methoxymethoxy)phenyl)but-3-en-2-one with 3-(4-(methoxymethoxy)phenyl)propanal, and then reacting the resultant with hydrochloric acid, so as to obtain 1,7-di-(4-hydroxyphenyl)-heptane-1,4-dien-3-one. The method is simple, easy to operate, has high yield, and can acheive high purity.
Inventors:
ZHAO YUNLI (CN)
YU ZHIGUO (CN)
MENG LIN (CN)
YU ZHIGUO (CN)
MENG LIN (CN)
Application Number:
PCT/CN2018/106953
Publication Date:
May 02, 2019
Filing Date:
September 21, 2018
Export Citation:
Assignee:
UNIV SHENYANG PHARMACEUTICAL (CN)
International Classes:
C07C45/65; A61P15/00; A61P35/00; C07C49/248
Foreign References:
| CN107721836A | 2018-02-23 | |||
| CN103936577A | 2014-07-23 | |||
| CN103819475A | 2014-05-28 | |||
| CN103910616A | 2014-07-09 |
Attorney, Agent or Firm:
SHENYANG JACK INTELLECTUAL PROPERTY AGENT LTD. (CN)
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