Title:
METHOD FOR SYNTHESIZING ARYL BENZYL THIOETHER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/031242
Kind Code:
A1
Abstract:
A method for synthesizing an aryl benzyl thioether compound using photocatalysis. By using the iron (III) complex [HIMXy Me][FeBr 4]([HIMXy Me]=l,3-bis(4-methoxy-2,6-dimethylphenyl)-4,5-dimethylimidazolium cation) as a catalyst, fac-Ir(ppy) 3(ppy=2-phenylpyridyl) as a photosensitizer, and DTBP (di-tert-butyl peroxide) as an oxidizing agent, a corresponding aryl benzyl thioether compound is synthesized by means of an oxidation, dehydrogenation and coupling reaction of a thiophenol compound with a toluene compound in the mere presence of visible light. The synthesis of the aryl benzyl thioether compound realized by the activation of an S-H bond and a C-H bond by the iron-based catalyst under illumination conditions can be smoothly carried out at room temperature; meanwhile, the iron (III) complex used has a clear structure and air stability, and the starting materials used in the reaction are cheap and readily available, which is conducive to large-scale synthesis application.
Inventors:
SUN HONGMEI (CN)
LI BEI (CN)
LI BEI (CN)
Application Number:
PCT/CN2022/110855
Publication Date:
February 15, 2024
Filing Date:
August 08, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07C321/28; B01J31/22; C07C319/14; C07C323/07; C07C323/09; C07C323/20; C07D213/70; C07D239/38; C07D277/74; C07D307/18
Foreign References:
| CN112521240A | 2021-03-19 | |||
| CN110483349A | 2019-11-22 | |||
| CN112694375A | 2021-04-23 | |||
| CN102887923A | 2013-01-23 | |||
| CN105001031A | 2015-10-28 | |||
| CN107456995A | 2017-12-12 |
Other References:
MA XIANTAO, ZHU YINGYING, YU JING, YAN RAN, XIE XIAONI, HUANG LIJUN, WANG QI, CHANG XUE-PING, XU QING: "Water oxidation by Brønsted acid-catalyzed in situ generated thiol cation: dual function of the acid catalyst leading to transition metal-free substitution and addition reactions of S–S bonds", ORGANIC CHEMISTRY FRONTIERS, vol. 9, no. 12, 14 June 2022 (2022-06-14), pages 3204 - 3214, XP093137890, ISSN: 2052-4129, DOI: 10.1039/D2QO00169A
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
Download PDF: