Title:
METHOD FOR SYNTHESIZING DESMOPRESSIN
Document Type and Number:
WIPO Patent Application WO/2020/248372
Kind Code:
A1
Abstract:
Provided is a method for synthesizing desmopressin, the method comprising the following steps: 1) selection of a solid carrier resin; 2) synthesis of a main chain peptide resin; 3) cracking same and removing the resin and a protecting group; and 4) carrying out liquid-phase electrochemical oxidation to couple a disulfide bond in order to obtain the desmopressin. This method can avoid the specific selectivity of a reaction, can improve the utilization of a fragment peptide resin, the utilization of the main chain fragment, and the atomic utilization, thereby reducing the production cost, avoiding the use of the chemical oxidants iodine and hydrogen peroxide, so that same is more environmentally friendly and more in line with the concept of green chemistry.
Inventors:
CHEN XUEMING (CN)
YUAN HUIXING (CN)
MI PENGCHENG (CN)
TAO ANJIN (CN)
YUAN JIANCHENG (CN)
YUAN HUIXING (CN)
MI PENGCHENG (CN)
TAO ANJIN (CN)
YUAN JIANCHENG (CN)
Application Number:
PCT/CN2019/102692
Publication Date:
December 17, 2020
Filing Date:
August 27, 2019
Export Citation:
Assignee:
HYBIO PHARMACEUTICAL WUHAN CO LTD (CN)
GANSU CHANGEE BIO PHARMACEUTICAL CO LTD (CN)
GANSU CHANGEE BIO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K1/00; C07K7/06; C07K1/02; C07K1/04; C07K1/06; C07K1/20; C07K1/24
Domestic Patent References:
| WO2011011342A1 | 2011-01-27 | |||
| WO2017114384A1 | 2017-07-06 |
Foreign References:
| CN102863513A | 2013-01-09 | |||
| CN104926927A | 2015-09-23 |
Other References:
PENGFEI HUANG, WANG PAN, TANG SHAN, FU ZHUANGJIONG, LEI AIWEN: "Electro-Oxidative S-H/S-H Cross-Coupling with Hydrogen Evolution: Facile Access to Unsymmetrical Disulfides", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 57, no. 27, 8 May 2018 (2018-05-08), pages 8115 - 8119, XP055763400, ISSN: 1433-7851, DOI: 10.1002/anie.201803464
BHASKARA REDDY K M; BHARATHI KUMARI Y; DOKKA MALLIKHARJUNASARMA; KAMANA BULLIRAJU; VANJIVAKA SREELATHA; KUPPANNA ANANDA: "Large Scale Solid Phase Synthesis of Peptide Drugs: Use of Commercial Anion Exchange Resin as Quenching Agent for Removal of Iodine during Disulphide Bond Formation", INTERNATIONAL JOURNAL OF PEPTIDES, vol. 2012, 1 January 2012 (2012-01-01), pages 1 - 8, XP055618213, ISSN: 1687-9767, DOI: 10.1155/2012/323907
IOANA ANNIS , LIN CHEN , GEORGE BARANY: "Novel Solid-Phase Reagents for Facile Formation of Intramolecular Disulfide Bridges in Peptides under Mild Conditions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 29, 1 January 1998 (1998-01-01), pages 7226 - 7238, XP002555112, ISSN: 0002-7863, DOI: 10.1021/ja981111p
BHASKARA REDDY K M; BHARATHI KUMARI Y; DOKKA MALLIKHARJUNASARMA; KAMANA BULLIRAJU; VANJIVAKA SREELATHA; KUPPANNA ANANDA: "Large Scale Solid Phase Synthesis of Peptide Drugs: Use of Commercial Anion Exchange Resin as Quenching Agent for Removal of Iodine during Disulphide Bond Formation", INTERNATIONAL JOURNAL OF PEPTIDES, vol. 2012, 1 January 2012 (2012-01-01), pages 1 - 8, XP055618213, ISSN: 1687-9767, DOI: 10.1155/2012/323907
IOANA ANNIS , LIN CHEN , GEORGE BARANY: "Novel Solid-Phase Reagents for Facile Formation of Intramolecular Disulfide Bridges in Peptides under Mild Conditions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 29, 1 January 1998 (1998-01-01), pages 7226 - 7238, XP002555112, ISSN: 0002-7863, DOI: 10.1021/ja981111p
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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