Title:
METHOD FOR SYNTHESIZING HIGH-PURITY PLANT-DERIVED CHOLESTEROL
Document Type and Number:
WIPO Patent Application WO/2023/142888
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for synthesizing high-purity plant-derived cholesterol. By taking plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, also called bisnoralcohol or BA, as a raw material, cholesterol is synthesized by means of steps such as oxidation, Wittig reaction, acetylation, reduction and selective hydrogenation reduction, or the cholesterol is synthesized by means of steps such as oxidation, Wittig reaction, acetylation, reduction, hydroxyl protection, selective hydrogenation reduction, deprotection or hydrolysis, and the purity can reach 99% or above. For the defect that there is cholesterol in a conventional animal source, according to the present invention, a plant-derived raw material, namely BA is used for synthesizing the cholesterol, such that the safety is high, the risk of pathogenic bacteria and virus infection is avoided, the synthesis yield is high, the product purity is good, the environment is friendly, and industrial production is facilitated; moreover, the present invention greatly reduces the impurity level in the product, facilitates the obtaining of high-purity cholesterol, and improves the safety of clinical use.
Inventors:
QIU WENWEI (CN)
GU XIANGZHONG (CN)
LI CHENCHEN (CN)
JIANG CHENGYU (CN)
YE RUFEI (CN)
GU XIANGZHONG (CN)
LI CHENCHEN (CN)
JIANG CHENGYU (CN)
YE RUFEI (CN)
Application Number:
PCT/CN2022/144011
Publication Date:
August 03, 2023
Filing Date:
December 30, 2022
Export Citation:
Assignee:
UNIV EAST CHINA NORMAL (CN)
JIANGSU JIAERKE PHARMACEUTICALS GROUP CORP LTD (CN)
JIANGSU JIAERKE PHARMACEUTICALS GROUP CORP LTD (CN)
International Classes:
C07J9/00
Foreign References:
| CN114524856A | 2022-05-24 | |||
| CN114874277A | 2022-08-09 | |||
| CN114395009A | 2022-04-26 | |||
| CN113248557A | 2021-08-13 | |||
| CN112608361A | 2021-04-06 | |||
| CN105218610A | 2016-01-06 | |||
| CN106632565A | 2017-05-10 |
Other References:
HIRANO YUTAKA, TAKATSUTO SUGURU, IKEKAWA NOBUO: "Further investigations of the stereochemistry of electrophilic addition reactions of the steroidal C-22 double bond", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, UK, 1 January 1984 (1984-01-01), Cambridge, UK , pages 1775 - 1779, XP093080945, ISSN: 0300-922X, DOI: 10.1039/p19840001775
ZHENG XIU-AN, KONG RUI, HUANG HUA-SHAN, WEI JING-YING, CHEN JI-ZONG, GONG SHAN-SHAN, SUN QI: "Hafnium Triflate as a Highly Potent Catalyst for Regio- and Chemoselective Deprotection of Silyl Ethers", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., vol. 51, no. 04, 1 February 2019 (2019-02-01), STUTTGART, DE. , pages 944 - 952, XP093080947, ISSN: 0039-7881, DOI: 10.1055/s-0037-1610307
ZHENG XIU-AN, KONG RUI, HUANG HUA-SHAN, WEI JING-YING, CHEN JI-ZONG, GONG SHAN-SHAN, SUN QI: "Hafnium Triflate as a Highly Potent Catalyst for Regio- and Chemoselective Deprotection of Silyl Ethers", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., vol. 51, no. 04, 1 February 2019 (2019-02-01), STUTTGART, DE. , pages 944 - 952, XP093080947, ISSN: 0039-7881, DOI: 10.1055/s-0037-1610307
Attorney, Agent or Firm:
MSJLAW OFFICE (CN)
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