Title:
METHOD FOR SYNTHESIZING ORGANIC MAGNESIUM COMPOUND, METHOD FOR SYNTHESIZING ORGANIC BORIC ACID COMPOUND, AND COUPLING METHOD
Document Type and Number:
WIPO Patent Application WO/2019/131898
Kind Code:
A1
Abstract:
The present invention realizes a technology that makes it possible to efficiently and inexpensively synthesize an organic magnesium compound simply, in a small number of steps, and without requiring cumbersome chemistry procedures. The present invention is a method for synthesizing an organic magnesium compound that comprises: a step in which, in a reaction solvent, an organic halide represented by general formula I (Ra–Xa) and a dispersion in which sodium is dispersed in a dispersion solvent are made to react to obtain an organic sodium compound represented by general formula II (Ra–Na); and a step in which the obtained organic sodium compound and a magnesium halide represented by general formula III (Mg–(Xb)2) are made to react to obtain an organic magnesium compound represented by general formula IV (Ra–Mg–Xb).
Inventors:
MURAKAMI YOSHIAKI (JP)
FUKUSHIMA MIYUKI (JP)
TAKAI KAZUHIKO (JP)
ASAKO SOBI (JP)
FUKUSHIMA MIYUKI (JP)
TAKAI KAZUHIKO (JP)
ASAKO SOBI (JP)
Application Number:
PCT/JP2018/048213
Publication Date:
July 04, 2019
Filing Date:
December 27, 2018
Export Citation:
Assignee:
KOBELCO ECO SOLUTIONS CO LTD (JP)
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
International Classes:
C07F3/02; C07C1/32; C07C15/27; C07F5/02; C07B61/00
Foreign References:
| JPS61109792A | 1986-05-28 | |||
| JPS3716023B1 |
Other References:
ROBERT M WASHBURN , ERNEST LEBENS , CHARLES F ALBRIGHT , FRANKLIN A BILLING : "Benzeneboronic anhydride", ORGANIC SYNTHESES, vol. 39, 1 January 1959 (1959-01-01), pages 1 - 5, XP055623636, ISSN: 0078-6209, DOI: 10.15227/orgsyn.039.0003
NOBUYUKI ASHIKARI: "Organoboron compounds", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 17, no. 6, 1959, Japan, pages 320 - 329, XP055623647
KOHEI TAMAO , KOJI SUMITANI , MAKOTO KUMADA : "Selective carbon-carbon bond formation by cross-coupling of Grignard reagents with organic halides. Catalysis by nickel-phosphine complexes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 94, no. 12, 14 June 1972 (1972-06-14), pages 4374 - 4376, XP055623667, DOI: :10.1021/ja00767a075
SHOSTAKOVSKII, M. F. : "Reaction between sodium acetylide and Grignard reagent", DOKLADY AKADEMII NAUK SSSR, vol. 167, no. 2, 30 November 1966 (1966-11-30), pages 365 - 368, XP009522175, ISSN: 0002-3264
NAKAJIMA, HIROKI ET AL.: "Preparation of aryl sodium compounds from aryl chlorides using sodium dispersion and its application to cross-coupling reaction", PROCEEDINGS OF THE CHEMICAL SOCIETY OF JAPAN, vol. 98, 6 March 2018 (2018-03-06), pages 2H2-02, XP009522030
See also references of EP 3733678A4
C. R. GUIBERTJ. L. LITTLE: "Ullmanns's Encyclopedia of Industrial Chemistry", 2005, WILEY-VCH VERLAG, article "Alkyl- and Arylboranes"
XU JIANTAO ET AL.: "Preparation of Triphenylboron", SHIYOU HUAGONG, vol. 42, no. 4, 2013, pages 415 - 418
NOBUYUKI ASHIKARI: "Organoboron compounds", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 17, no. 6, 1959, Japan, pages 320 - 329, XP055623647
KOHEI TAMAO , KOJI SUMITANI , MAKOTO KUMADA : "Selective carbon-carbon bond formation by cross-coupling of Grignard reagents with organic halides. Catalysis by nickel-phosphine complexes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 94, no. 12, 14 June 1972 (1972-06-14), pages 4374 - 4376, XP055623667, DOI: :10.1021/ja00767a075
SHOSTAKOVSKII, M. F. : "Reaction between sodium acetylide and Grignard reagent", DOKLADY AKADEMII NAUK SSSR, vol. 167, no. 2, 30 November 1966 (1966-11-30), pages 365 - 368, XP009522175, ISSN: 0002-3264
NAKAJIMA, HIROKI ET AL.: "Preparation of aryl sodium compounds from aryl chlorides using sodium dispersion and its application to cross-coupling reaction", PROCEEDINGS OF THE CHEMICAL SOCIETY OF JAPAN, vol. 98, 6 March 2018 (2018-03-06), pages 2H2-02, XP009522030
See also references of EP 3733678A4
C. R. GUIBERTJ. L. LITTLE: "Ullmanns's Encyclopedia of Industrial Chemistry", 2005, WILEY-VCH VERLAG, article "Alkyl- and Arylboranes"
XU JIANTAO ET AL.: "Preparation of Triphenylboron", SHIYOU HUAGONG, vol. 42, no. 4, 2013, pages 415 - 418
Attorney, Agent or Firm:
R&C IP LAW FIRM (JP)
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