Title:
METHOD FOR SYNTHESIZING THIOHYDANTOIN DERIVATIVE BY MEANS OF ONE-STEP METHOD
Document Type and Number:
WIPO Patent Application WO/2022/206742
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of medicine synthesis, and in particular relates to a method for synthesizing a thiohydantoin derivative by means of a one-step method. By means of taking three components, i.e., an amino acid derivative, an amino compound (especially an arylamine compound) and a thio-source reagent, as raw materials, a thiohydantoin derivative can be directly prepared by means of a one-pot method. Thus, first preparing isothiocyanate (a compound containing a -NCS group), and separating and purifying the isothiocyanate are not necessary, so that the reaction period is greatly shortened, and the production cost is reduced; moreover, the use of an acid and an alkali in the reaction process are avoided, thereby achieving environmental protection.
Inventors:
TONG YOUZHI (CN)
XU RUO (CN)
WU XIAOJUN (CN)
SHEN JIANBING (CN)
XU RUO (CN)
WU XIAOJUN (CN)
SHEN JIANBING (CN)
Application Number:
PCT/CN2022/083607
Publication Date:
October 06, 2022
Filing Date:
March 29, 2022
Export Citation:
Assignee:
SUZHOU KINTOR PHARMACEUTICALS INC (CN)
International Classes:
C07D413/14; C07D233/86; C07D401/02
Domestic Patent References:
| WO2015092617A1 | 2015-06-25 | |||
| WO2015063720A1 | 2015-05-07 |
Foreign References:
| CN1500081A | 2004-05-26 | |||
| CN103108549A | 2013-05-15 | |||
| CN1399631A | 2003-02-26 | |||
| CN102639523A | 2012-08-15 | |||
| CN101460467A | 2009-06-17 | |||
| CN104003939A | 2014-08-27 |
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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