Title:
METHOD, SYSTEM, COMPOSITION, AND KIT FOR DIAGNOSING AND IDENTIFYING NON-ALZHEIMER'S DISEASE COGNITIVE DISORDER
Document Type and Number:
WIPO Patent Application WO/2023/232108
Kind Code:
A1
Abstract:
A method, system, composition, and kit for diagnosing and identifying a non-Alzheimer's disease (AD) cognitive disorder, i.e., a "non-AD cognitive disorder". The system for diagnosing a "non-AD cognitive disorder" comprises: a first examination module used for examining the central nervous system source biomarker of extracellular vesicles (EV) in the body fluid of a test subject, so as to confirm the number and the particle size of the EVs carrying the central nervous system source-specific marker; a second examination module used for examining the marker related to the non-AD cognitive disorder of the EV in the body fluid of the test subject so as to confirm the number and the particle size of the EVs carrying the marker related to the non-AD cognitive disorder; and a diagnosis and identification module for diagnosing whether the test subject suffers from a non-AD cognitive disorder, the diagnosis being based on the examination results of the central nervous system source marker and the marker related to the non-AD cognitive disorder respectively obtained by the first examination module and the second examination module.
Inventors:
ZHANG JING (CN)
TIAN CHEN (CN)
GUO ZHEN (CN)
TIAN CHEN (CN)
GUO ZHEN (CN)
Application Number:
PCT/CN2023/097777
Publication Date:
December 07, 2023
Filing Date:
June 01, 2023
Export Citation:
Assignee:
THE FIRST AFFILIATED HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE (CN)
UNIV ZHEJIANG (CN)
UNIV ZHEJIANG (CN)
International Classes:
G01N33/68; G01N15/02; G01N15/10; G01N33/53
Domestic Patent References:
| WO2021228067A1 | 2021-11-18 | |||
| WO2019144056A1 | 2019-07-25 | |||
| WO2021107154A1 | 2021-06-03 |
Foreign References:
| CN110133272A | 2019-08-16 | |||
| CN111279196A | 2020-06-12 | |||
| CN113614531A | 2021-11-05 | |||
| TW201606307A | 2016-02-16 | |||
| CN116793909A | 2023-09-22 |
Other References:
KARAMI AZADEH, DARREH-SHORI TAHER, SCHULTZBERG MARIANNE, ERIKSDOTTER MARIA: "CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment", FRONTIERS IN AGING NEUROSCIENCE, FRONTIERS RESEARCH FOUNDATION, CH, vol. 13, 26 August 2021 (2021-08-26), CH , pages 704583, XP093117156, ISSN: 1663-4365, DOI: 10.3389/fnagi.2021.704583
JIA LONGFEI; QIU QIONGQIONG; ZHANG HENG; CHU LAN; DU YIFENG; ZHANG JIEWEN; ZHOU CHUNKUI; LIANG FURU; SHI SHENGLIANG; WANG SHAN; QI: "Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid", ALZHEIMER'S & DEMENTIA, ELSEVIER, NEW YORK, NY, US, vol. 15, no. 8, 1 August 2019 (2019-08-01), US , pages 1071 - 1080, XP085774656, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2019.05.002
MATTSSON-CARLGREN NIKLAS, JANELIDZE SHORENA, PALMQVIST SEBASTIAN, CULLEN NICHOLAS, SVENNINGSSON ANNA L, STRANDBERG OLOF, MENGEL DA: "Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease", BRAIN, OXFORD UNIVERSITY PRESS, GB, vol. 143, no. 11, 1 November 2020 (2020-11-01), GB , pages 3234 - 3241, XP093068836, ISSN: 0006-8950, DOI: 10.1093/brain/awaa286
PALMQVIST SEBASTIAN, JANELIDZE SHORENA, QUIROZ YAKEEL T., ZETTERBERG HENRIK, LOPERA FRANCISCO, STOMRUD ERIK, SU YI, CHEN YINGHUA, : "Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 324, no. 8, 25 August 2020 (2020-08-25), US , pages 772, XP093068802, ISSN: 0098-7484, DOI: 10.1001/jama.2020.12134
JIA LONGFEI; QIU QIONGQIONG; ZHANG HENG; CHU LAN; DU YIFENG; ZHANG JIEWEN; ZHOU CHUNKUI; LIANG FURU; SHI SHENGLIANG; WANG SHAN; QI: "Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid", ALZHEIMER'S & DEMENTIA, ELSEVIER, NEW YORK, NY, US, vol. 15, no. 8, 1 August 2019 (2019-08-01), US , pages 1071 - 1080, XP085774656, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2019.05.002
MATTSSON-CARLGREN NIKLAS, JANELIDZE SHORENA, PALMQVIST SEBASTIAN, CULLEN NICHOLAS, SVENNINGSSON ANNA L, STRANDBERG OLOF, MENGEL DA: "Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease", BRAIN, OXFORD UNIVERSITY PRESS, GB, vol. 143, no. 11, 1 November 2020 (2020-11-01), GB , pages 3234 - 3241, XP093068836, ISSN: 0006-8950, DOI: 10.1093/brain/awaa286
PALMQVIST SEBASTIAN, JANELIDZE SHORENA, QUIROZ YAKEEL T., ZETTERBERG HENRIK, LOPERA FRANCISCO, STOMRUD ERIK, SU YI, CHEN YINGHUA, : "Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 324, no. 8, 25 August 2020 (2020-08-25), US , pages 772, XP093068802, ISSN: 0098-7484, DOI: 10.1001/jama.2020.12134
Attorney, Agent or Firm:
BEIJING TANGSONG IP FIRM (CN)
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