METHOD AND SYSTEM FOR MRI-BASED TARGETING, MONITORING, AND QUANTIFICATION OF THERMAL AND MECHANICAL BIOEFFECTS IN TISSUE INDUCED BY HIGH INTENSITY FOCUSED ULTRASOUND

Title:

METHOD AND SYSTEM FOR MRI-BASED TARGETING, MONITORING, AND QUANTIFICATION OF THERMAL AND MECHANICAL BIOEFFECTS IN TISSUE INDUCED BY HIGH INTENSITY FOCUSED ULTRASOUND

Document Type and Number:

WIPO Patent Application WO/2015/148938

Kind Code:

A3

Abstract:

Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as "boiling histotripsy" (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.

Inventors:

PARTANEN ARI (US)
KHOKHLOVA VERA (US)
FARR NAVID (US)
LEE DONGHOON (US)
KREIDER WAYNE (US)
KHOKHLOVA TATIANA (US)
MAXWELL ADAM (US)
WANG YAK-NAM (US)
SCHADE GEORGE (US)
BAILEY MICHAEL (US)

Application Number:

PCT/US2015/023021

Publication Date:

November 26, 2015

Filing Date:

March 27, 2015

Export Citation:

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Assignee:

PARTANEN ARI (US)
KHOKHLOVA VERA (US)
FARR NAVID (US)
LEE DONGHOON (US)
KREIDER WAYNE (US)
KHOKHLOVA TATIANA (US)
MAXWELL ADAM (US)
WANG YAK-NAM (US)
SCHADE GEORGE (US)
BAILEY MICHAEL (US)

International Classes:

A61B8/00; A61N7/02

Domestic Patent References:

WO2013153506A1

2013-10-17

Foreign References:

US20130102932A1	2013-04-25
US6522142B1	2003-02-18
US20120232388A1	2012-09-13

Other References:

DAMIANOU, C ET AL.: "MRI monitoring of lesions created at temperature below the boiling point and of lesions created above the boiling point using high intensity focused ultrasound.", JOURNAL OF BIOMEDICAL SCIENCE AND ENGINEERING., vol. 03, no. 08, 3 August 2010 (2010-08-03), pages 764 - 775, XP055238253, ISSN: 1937-6871

Attorney, Agent or Firm:

HARPER, David, S. (300 South Wacker DriveChicago, IL, US)

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