Title:
METHOD AND SYSTEM FOR SELECTING THERAPEUTIC TARGETS USING MOLECULAR INTERACTION DYNAMIC NETWORKS
Document Type and Number:
WIPO Patent Application WO2005013173
Kind Code:
A3
Abstract:
The invention concerns the field of integrative analysis of molecular interactions in a biological system. In particular, the invention concerns a method for obtaining a dynamic model of a network of molecular interactions in a biological system, enabling said interactions to be analyzed when a stimulus is applied to the dynamic model, in particular to establish a hierarchy of biological molecules or to select therapeutic targets with respect to a specific biological problem, in particular to define a therapeutic action to be applied to said molecules. The invention also concerns a computer system for obtaining a dynamic model of a network of molecular interactions in a biological system, and the analysis of said molecular interactions when a stimulus is applied to the dynamic model, the computer system comprising at least one central processing unit connected to at least one quantitative experimental database.
Inventors:
VUJASINOVIC TODOR (FR)
Application Number:
PCT/FR2004/002064
Publication Date:
September 29, 2005
Filing Date:
July 30, 2004
Export Citation:
Assignee:
HELIOS BIOSCIENCES (FR)
VUJASINOVIC TODOR (FR)
VUJASINOVIC TODOR (FR)
International Classes:
G16B5/30; G16B5/10; G16B5/20; (IPC1-7): G06F19/00
Domestic Patent References:
| WO2002044992A2 | 2002-06-06 | |||
| WO2003017127A2 | 2003-02-27 |
Other References:
GORYANIN I ET AL: "Mathematical simulation and analysis of cellular metabolism and regulation", BIOINFORMATICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 15, no. 9, September 1999 (1999-09-01), pages 749 - 758, XP002190906, ISSN: 1367-4803
CURTO R ET AL: "Mathematical models of purine metabolism in man", MATHEMATICAL BIOSCIENCES, ELSEVIER, NEW YORK, NY, US, vol. 151, no. 1, July 1998 (1998-07-01), pages 1 - 49, XP002250783, ISSN: 0025-5564
SEDAGHAT AHMAD R ET AL: "A mathematical model of metabolic insulin signaling pathways.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 283, no. 5 Part 1, November 2002 (2002-11-01), pages E1084 - E1101, XP002289933, ISSN: 0002-9513
CURTO R ET AL: "Mathematical models of purine metabolism in man", MATHEMATICAL BIOSCIENCES, ELSEVIER, NEW YORK, NY, US, vol. 151, no. 1, July 1998 (1998-07-01), pages 1 - 49, XP002250783, ISSN: 0025-5564
SEDAGHAT AHMAD R ET AL: "A mathematical model of metabolic insulin signaling pathways.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 283, no. 5 Part 1, November 2002 (2002-11-01), pages E1084 - E1101, XP002289933, ISSN: 0002-9513
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