A METHOD OF TESTING A CELL SAMPLE

Title:

A METHOD OF TESTING A CELL SAMPLE

Document Type and Number:

WIPO Patent Application WO2000039560

Kind Code:

A3

Abstract:

The present invention measures agglutination using a process which is capable of testing how tightly agglutinated cells are bonded by measuring how much force is required to separate them. By causing red cells which are approximately biconcave discs to sphere, the effective surface area available for bonding diminishes. Sphering a cell increases the space between antigen binding sites and increases the mean distance across which bonding occurs. As the surface area available for bonding between cells decreases as cells sphere they lose bonding strength, thus allowing clumped cells to separate. By recording the inducing pressure and the number of cells (or quantities related to it) as they change with respect to the inducing pressure, agglutination can be detected, quantified and monitored. This provides a simple but effective test for blood grouping and cross-matching by introducing an appropriate source of antibodies and detecting whether or not agglutination occurs.

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Inventors:

SHINE IAN BASIL (US)
SHINE THOMAS ADAM (US)

Application Number:

PCT/GB1999/004438

Publication Date:

September 21, 2000

Filing Date:

December 24, 1999

Export Citation:

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Assignee:

SHINE IAN BASIL (US)
SHINE THOMAS ADAM (US)

International Classes:

G01N33/48; G01N33/49; G01N33/53; (IPC1-7): G01N15/02; G01N33/80; G01N33/49; G01N33/86

Foreign References:

US4900685A	1990-02-13
US5510261A	1996-04-23
US5064765A	1991-11-12
US5350652A	1994-09-27
GB2186684A	1987-08-19

Other References: