Title:
METHOD FOR TESTING LEUKODERMA TOXICITY AND MELANOSIS TOXICITY
Document Type and Number:
WIPO Patent Application WO/2017/203999
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an evaluation method that can evaluate leukoderma toxicity or melanosis toxicity at high sensitivities. Provided is a leukoderma toxicity test method comprising a step for applying a test substance to the tail of a hairless mouse that can produce melanin, and a step for evaluating the presence/absence and/or degree of induction of leukoderma on the tail of the hairless mouse and scoring the leukoderma toxicity of the test substance on the basis of the results of the evaluation.
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Inventors:
KATO MASASHI (JP)
IIDA MACHIKO (JP)
IIDA MACHIKO (JP)
Application Number:
PCT/JP2017/017957
Publication Date:
November 30, 2017
Filing Date:
May 11, 2017
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
International Classes:
C12Q1/68; A01K67/027; G01N33/15; G01N33/50; C12N15/09
Foreign References:
| JP2013106554A | 2013-06-06 |
Other References:
ABE, YUKO ET AL.: "Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 81, January 2016 (2016-01-01), pages 35 - 43, XP029373491, DOI: doi:10.1016/j.jdermsci.2015.10.011
HARRIS, JOHN E. ET AL.: "A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-gamma for Autoreactive CD 8+ T- Cell Accumulation in the Skin", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, 2012, pages 1869 - 1876, XP055455909, DOI: doi:10.1038/jid.2011.463
11 February 2009 (2009-02-11), Retrieved from the Internet [retrieved on 20170726]
YUMI AOYAMA ET AL.: "The First Epidemiological Report of Rhododenol-induced Leukoderma in Japan Based on a Nationwide Survey", JAPANESE JOURNAL OF DERMATOLOGY, vol. 124, no. 11, 2014, pages 2095 - 2109
SASAKI, MINORU ET AL.: "Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism", PIGMENT CELL MELANOMA RES., vol. 27, 2014, pages 754 - 763, XP055600624
HARRIS, JOHN E. ET AL.: "A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-gamma for Autoreactive CD 8+ T- Cell Accumulation in the Skin", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, 2012, pages 1869 - 1876, XP055455909, DOI: doi:10.1038/jid.2011.463
11 February 2009 (2009-02-11), Retrieved from the Internet
YUMI AOYAMA ET AL.: "The First Epidemiological Report of Rhododenol-induced Leukoderma in Japan Based on a Nationwide Survey", JAPANESE JOURNAL OF DERMATOLOGY, vol. 124, no. 11, 2014, pages 2095 - 2109
SASAKI, MINORU ET AL.: "Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism", PIGMENT CELL MELANOMA RES., vol. 27, 2014, pages 754 - 763, XP055600624
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
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