Title:
METHOD FOR TREATING ADAMTS-5-ASSOCIATE DISEASE
Document Type and Number:
WIPO Patent Application WO/2005/060456
Kind Code:
A9
Abstract:
The present invention relates to methods of treating ADAMTS-S-associated diseases and particularly osteoarthritis comprising administering an agent capable an of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulfonamide compound. The invention is based, in part, on the discovery that transgenic animals that do not express functional ADAMTS-5 show a reduction in the degree of osteoarthritis after the induction of osteoarthritis as compared to WT animals. Furthermore, the ADAMTS-5 transgenic animals have reduced aggrecanase activity in articular tissue as compared to WT animals. These animals aye good models for ADAMTS-S-associated diseases, and for screening of drugs useful in the treatment and/or prevention of these diseases. These are no other animal models in which the deletion of the activity of a single gene is capable of abrogating the course of osteoarthritis. Accordingly, these animals also show that osteoarthritis can be prevented and/or treated by administering to a subject an ADAMTS-5 inhibitory agent and particularly an agent A0@0ble of inhibiting the aggrecanase activity of ADAMTS-5. Figure 1 illustrates the targeted disruption of the murine ADAMTS-5 gene.
Inventors:
MORRIS ELISABETH A (US)
GLASSON SONYA S (US)
XIANG JASON SHAOYUN (US)
GLASSON SONYA S (US)
XIANG JASON SHAOYUN (US)
Application Number:
PCT/US2004/037169
Publication Date:
May 05, 2011
Filing Date:
November 08, 2004
Export Citation:
Assignee:
WYETH CORP (US)
MORRIS ELISABETH A (US)
GLASSON SONYA S (US)
XIANG JASON SHAOYUN (US)
MORRIS ELISABETH A (US)
GLASSON SONYA S (US)
XIANG JASON SHAOYUN (US)
International Classes:
A61K31/19; A61K31/425; A61K31/47; A61K31/54; C07C311/29; C07C311/46; C07D213/30; C07D213/64; C07D213/643; C07D215/14; C07D215/227; C07D215/233; C07D217/18; C07D235/12; C07D239/34; C07D239/60; C07D261/14; C07D263/22; C07D263/58; C07D277/64; C07D277/68; C07D295/096; C07D295/192; C07D307/79; C07D307/80; C07D307/82; C07D307/84; C07D319/18; C07D321/10; C07D333/20; C07D333/36; C07D333/66; C12N9/50; C12N9/64; C07D215/22
Attorney, Agent or Firm:
PERRY, Lawrence, S. et al. (Cella Harper & Scinto,30 Rockefeller Plaz, New York NY, US)
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