Title:
METHOD FOR TREATING CANCER WITH A DNA DAMAGE REPAIR ENZYME INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/192505
Kind Code:
A3
Abstract:
Disclosed is a method for treating cancer by administering a damage repair (DDR) enzyme inhibitor to a patient in need thereof whose cancer cells are suspected of or have a deficiency of a DNA repair enzyme.
Inventors:
WEBER ECKARD (US)
Application Number:
PCT/US2023/016940
Publication Date:
November 09, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
PRIMEFOUR THERAPEUTICS INC (US)
International Classes:
A61P35/00; C07D473/18; C07D487/04; A61K31/505; A61K31/522
Domestic Patent References:
| WO2022066882A1 | 2022-03-31 |
Foreign References:
| US20040096863A1 | 2004-05-20 | |||
| US20170219565A1 | 2017-08-03 | |||
| US20210246120A1 | 2021-08-12 | |||
| US20160000854A1 | 2016-01-07 |
Other References:
HARAGUCHI ET AL.: "Synthesis of 4,-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI", ACS MEDICINAL CHEMISTRY LETTERS, vol. 2, 20 July 2011 (2011-07-20), pages 692 - 697, XP055194250, Retrieved from the Internet [retrieved on 20230704], DOI: 10.1021/ml2001054
KAMINSKI ANDREA M.; BEBENEK KATARZYNA; PEDERSEN LARS C.; KUNKEL THOMAS A.: "DNA polymerase mu: An inflexible scaffold for substrate flexibility", DNA REPAIR, ELSEVIER, AMSTERDAM, NL, vol. 93, 1 September 2020 (2020-09-01), NL , XP086302417, ISSN: 1568-7864, DOI: 10.1016/j.dnarep.2020.102932
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "SID 38610986", XP093109635, retrieved from PUBCHEM
KAMINSKI ANDREA M.; BEBENEK KATARZYNA; PEDERSEN LARS C.; KUNKEL THOMAS A.: "DNA polymerase mu: An inflexible scaffold for substrate flexibility", DNA REPAIR, ELSEVIER, AMSTERDAM, NL, vol. 93, 1 September 2020 (2020-09-01), NL , XP086302417, ISSN: 1568-7864, DOI: 10.1016/j.dnarep.2020.102932
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "SID 38610986", XP093109635, retrieved from PUBCHEM
Attorney, Agent or Firm:
GROSS III, Michael F. et al. (US)
Download PDF: