Title:
METHOD FOR TREATING CORONAVIRUS BY USING ACE-2-FC FUSION PROTEIN
Document Type and Number:
WIPO Patent Application WO/2021/170113
Kind Code:
A1
Abstract:
A method for treating coronavirus by using an ACE-2-Fc fusion protein, relating to the field of virus treatment. A recombinant fusion protein, wherein the protein comprises an angiotensin-converting enzyme 2 (ACE2) region connected to an Fc region of immunoglobulin, and the fusion protein can bind to a coronavirus spike protein, thereby blocking the binding of ACE2 to the coronavirus spike protein. A method for preventing, treating or relieving coronavirus infections. The method comprises administrating a protein comprising an ACE2 extracellular domain to a subject infected or suspected to be infected with coronavirus, the coronavirus being SARS-Cov-2, and the ACE2 extracellular domain comprising an amino acid sequence represented by SEQ ID NO: 1, wherein the protein exists in the form of a dimer.
Inventors:
WANG WEIMING (CN)
ZENG MING (US)
ZHANG XIAN (CN)
WU BO (CN)
ZENG MING (US)
ZHANG XIAN (CN)
WU BO (CN)
Application Number:
PCT/CN2021/078270
Publication Date:
September 02, 2021
Filing Date:
February 26, 2021
Export Citation:
Assignee:
NANJING GENSCRIPT BIOTECH CO LTD (CN)
NANJING LEGEND BIOTECH CO LTD (CN)
NANJING LEGEND BIOTECH CO LTD (CN)
International Classes:
C07K19/00; A61K38/48; A61K47/68; A61P29/00; C12N9/48; C12N15/62
Domestic Patent References:
| WO2006136084A1 | 2006-12-28 | |||
| WO2018140456A1 | 2018-08-02 | |||
| WO2006122819A1 | 2006-11-23 | |||
| WO2005028497A2 | 2005-03-31 |
Foreign References:
| CN110114369A | 2019-08-09 | |||
| CN107569679A | 2018-01-12 |
Other References:
CHANGHAI LEI, WENYAN FU, KEWEN QIAN, TIAN LI, SHENG ZHANG, MIN DING, SHI HU: "Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig", BIORXIV, 3 February 2020 (2020-02-03), XP055745522, Retrieved from the Internet DOI: 10.1101/2020.02.01.929976
PAN LIU, WYSOCKI JAN, SOUMA TOMOKAZU, YE MINGHAO, RAMIREZ VERONICA, ZHOU BISHENG, WILSBACHER LISA D., QUAGGIN SUSAN E., BATLLE DAN: "Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 94, no. 1, 1 July 2018 (2018-07-01), GB, pages 114 - 125, XP055745670, ISSN: 0085-2538, DOI: 10.1016/j.kint.2018.01.029
PAN LIU, WYSOCKI JAN, SOUMA TOMOKAZU, YE MINGHAO, RAMIREZ VERONICA, ZHOU BISHENG, WILSBACHER LISA D., QUAGGIN SUSAN E., BATLLE DAN: "Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 94, no. 1, 1 July 2018 (2018-07-01), GB, pages 114 - 125, XP055745670, ISSN: 0085-2538, DOI: 10.1016/j.kint.2018.01.029
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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