Title:
METHOD FOR TREATING HEART FAILURE WITH STRESSCOPIN-LIKE PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2011/057027
Kind Code:
A3
Abstract:
The present invention relates to novel methods of treating heart failure comprising administering an amount of stresscopin-like peptide to a subject in need thereof; and substantially maintaining the amount of said peptide present in the plasma of said subject at a concentration resulting in a therapeutic benefit without a substantial increase in the heart rate of said subject. The method involves the use of stresscopin-like peptides that are selective corticotrophin releasing hormone receptor type 2 (CRHR2) agonists.
Inventors:
GENGO PETER J (US)
SABBAH HANI N (US)
SHANKLEY NIGEL P (US)
SABBAH HANI N (US)
SHANKLEY NIGEL P (US)
Application Number:
PCT/US2010/055526
Publication Date:
July 07, 2011
Filing Date:
November 04, 2010
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
GENGO PETER J (US)
SABBAH HANI N (US)
SHANKLEY NIGEL P (US)
GENGO PETER J (US)
SABBAH HANI N (US)
SHANKLEY NIGEL P (US)
International Classes:
A61K38/22
Domestic Patent References:
| WO2010053990A2 | 2010-05-14 | |||
| WO2008047241A2 | 2008-04-24 | |||
| WO2002074326A2 | 2002-09-26 | |||
| WO2009027844A2 | 2009-03-05 |
Other References:
BRAR BHAWANJIT K ET AL: "Urocortin-II and Urocortin-III are cardioprotective against ischemia reperfusion injury: An essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 145, no. 1, 1 January 2004 (2004-01-01), pages 24 - 35, XP002565609, ISSN: 0013-7227, DOI: DOI:10.1210/EN.2003-0689
Attorney, Agent or Firm:
JOHNSON, Philip, S. et al. (One Johnson & Johnson PlazaNew Brunswick, NJ, US)
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