Title:
METHOD OF TREATING PROSTATIC DISEASES USING DELAYED AND/OR SUSTAINED RELEASE VITAMIN D FORMULATIONS
Document Type and Number:
WIPO Patent Application WO1998029105
Kind Code:
A3
Abstract:
Method of treating prostatic conditions such as prostate cancer and hyperplasia by administering 1 alpha -hydroxyprevitamin D or activated vitamin D or a combination thereof in a sustained release form or a delayed and sustained release formulation. Both the sustained release form and the delayed, sustained release form deliver increased active vitamin D blood levels without significant risk of hypercalcemia associated with other oral dosing of vitamin D forms, to provide the beneficial effect to the diseased prostate tissue.
Inventors:
BISHOP CHARLES W
KNUTSON JOYCE C
VALLIERE CHARLES R
KNUTSON JOYCE C
VALLIERE CHARLES R
Application Number:
PCT/US1997/022034
Publication Date:
October 15, 1998
Filing Date:
December 10, 1997
Export Citation:
Assignee:
BONE CARE INT INC (US)
International Classes:
A61K9/50; A61K9/52; A61K9/30; A61K31/17; A61K31/198; A61K31/407; A61K31/513; A61K31/519; A61K31/565; A61K31/573; A61K31/59; A61K31/66; A61K31/704; A61K33/243; A61K38/23; A61P13/00; A61P35/00; (IPC1-7): A61K31/00; A61K31/59
Domestic Patent References:
| WO1997000242A1 | 1997-01-03 |
Other References:
SKOWRONSKI ET AL.: "Actions of Vitamin D3 Analogs on Human Prostate Cancer Cell Lines: Comparison with 1,25-Dihydroxyvitamin D3", ENDOCRINOLOGY, vol. 136, no. 1, January 1995 (1995-01-01), pages 20 - 26, XP002058578
SCHWARTZ ET AL.: "1,25-Dihydroxy-16-ene-23-yne-vitamin D3 and Prostate Cancer Cell Proliferation In Vivo", UROLOGY, vol. 46, no. 3, September 1995 (1995-09-01), pages 365 - 369, XP002058579
FELDMAN ET AL.: "Vitamin D and Prostate Cancer", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 375, 1995, pages 53 - 63, XP002058580
PEEHL ET AL.: "Antiproliferative Effects of 1,25-Dihydroxyvitamin D3 on Primary Cultures of Human Prostatic Cells", CANCER RESEARCH, vol. 54, 1 February 1994 (1994-02-01), pages 805 - 810, XP002058581
MILLER ET AL.: "Vitamin D Receptor Expression, 24-Hydroxylase Activity, and Inhibition of Growth by 1alpha,25-Dihydroxyvitamin D3 in Seven Human Prostatic Carcinoma Cell Lines", CLINICAL CANCER RESEARCH, vol. 1, September 1995 (1995-09-01), pages 997 - 1003, XP002058582
DATABASE MEDLINE STN; XP002058583
SCHWARTZ ET AL.: "1,25-Dihydroxy-16-ene-23-yne-vitamin D3 and Prostate Cancer Cell Proliferation In Vivo", UROLOGY, vol. 46, no. 3, September 1995 (1995-09-01), pages 365 - 369, XP002058579
FELDMAN ET AL.: "Vitamin D and Prostate Cancer", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 375, 1995, pages 53 - 63, XP002058580
PEEHL ET AL.: "Antiproliferative Effects of 1,25-Dihydroxyvitamin D3 on Primary Cultures of Human Prostatic Cells", CANCER RESEARCH, vol. 54, 1 February 1994 (1994-02-01), pages 805 - 810, XP002058581
MILLER ET AL.: "Vitamin D Receptor Expression, 24-Hydroxylase Activity, and Inhibition of Growth by 1alpha,25-Dihydroxyvitamin D3 in Seven Human Prostatic Carcinoma Cell Lines", CLINICAL CANCER RESEARCH, vol. 1, September 1995 (1995-09-01), pages 997 - 1003, XP002058582
DATABASE MEDLINE STN; XP002058583
Download PDF: