Title:
METHOD OF TREATING TRX MEDIATED DISEASES
Document Type and Number:
WIPO Patent Application WO2003070188
Kind Code:
A3
Abstract:
The present invention provides a novel method for treating and/or preventing thioredoxin (TRX)-mediated diseases and conditions, by administering to a subject in need of such treatment a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof. The HDAC inhibitor can alter the expression of a thioredoxin-binding-protein (e.g. TBP-2), which in turn can lead to an altered TRX/thioredoxin-binding-protein cellular binding interaction, resulting in an increase or decrease in the level or activity of cellular TRX, for example the expression level or reducing activity of TRX. Thus the present invention relates to the use of HDAC inhibitors in a method of preventing and/or treating a wide variety of thioredoxin (TRX)-mediated diseases and conditions, such as inflammatory diseases, allergic diseases, autoimmune diseases, diseases associated with oxidative stress or diseases characterized by cellular hyperproliferation.
Inventors:
RICHON VICTORIA M (US)
MARKS PAUL A (US)
RIFKIND RICHARD A (US)
BUTLER LISA M (AU)
MARKS PAUL A (US)
RIFKIND RICHARD A (US)
BUTLER LISA M (AU)
Application Number:
PCT/US2003/004924
Publication Date:
February 19, 2004
Filing Date:
February 14, 2003
Export Citation:
Assignee:
SLOAN KETTERING INST CANCER (US)
RICHON VICTORIA M (US)
MARKS PAUL A (US)
RIFKIND RICHARD A (US)
BUTLER LISA M (AU)
RICHON VICTORIA M (US)
MARKS PAUL A (US)
RIFKIND RICHARD A (US)
BUTLER LISA M (AU)
International Classes:
A61K31/00; C12N15/09; A61K31/12; A61K31/121; A61K31/16; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/19; A61K31/192; A61K31/275; A61K31/336; A61K31/4045; A61K31/435; A61K31/4406; A61K38/00; A61K38/12; A61K38/15; A61K45/00; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/10; A61P5/14; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P35/04; A61P37/00; A61P37/02; A61P37/08; A61P39/00; A61P41/00; A61P43/00; (IPC1-7): A61K38/00
Foreign References:
| US5993845A | 1999-11-30 |
Other References:
See also references of EP 1482962A4
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