Title:
METHOD OF TREATING TUMORS
Document Type and Number:
WIPO Patent Application WO2004010951
Kind Code:
A3
Abstract:
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.
Inventors:
DENARDO SALLY J
BURKE PATRICIA A
DENARDO GERALD L
GOODMAN SIMON
MATZKU SIEGFRIED DI
BURKE PATRICIA A
DENARDO GERALD L
GOODMAN SIMON
MATZKU SIEGFRIED DI
Application Number:
PCT/US2003/023845
Publication Date:
December 16, 2004
Filing Date:
July 30, 2003
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
MERCK PATENT GMBH (DE)
MERCK PATENT GMBH (DE)
International Classes:
A61K38/12; A61K51/08; A61P7/00; A61P9/00; A61P19/00; A61K38/00; A61P27/00; A61P31/00; A61P35/00; C07K16/30; (IPC1-7): A61K38/00; A61K38/12; A61K51/00; A61K51/08; A61K51/10
Other References:
DATABASE CAPLUS [online] 7 July 2000 (2000-07-07), MCKEARN J P ET AL: "Method of using a cyclooxygenase-2 inhibitor and an integrin antagonist as a combination therapy in the treatment of neoplasia", XP002903569, accession no. STN Database accession no. 2000:456950
DATABASE CAPLUS [online] 7 July 2000 (2000-07-07), MCKEARN J P ET AL: "Method of using an intergrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia", XP002903570, accession no. stn Database accession no. 2000:456866
DATABASE CAPLUS [online] 7 July 2000 (2000-07-07), MCKEARN J P ET AL: "Use of a matrix metalloproteinase inhibitor and an integrin antagonist in the treatment of neoplasia", XP002903571, accession no. STN Database accession no. 2000:456916
DATABASE CAPLUS [online] 12 March 2000 (2000-03-12), DENARDO S J ET AL: "Neovascular targeting with cyclic RGD peptide (cRGDf-ACHA) to enhance delivery of radioimmunotherapy", XP002903567, accession no. STN Database accession no. 2000:162464
DATABASE CAPLUS [online] 21 December 2000 (2000-12-21), KESSLER H ET AL: "Recent progress in the field of .alpha.v-integrin antagonists", XP002903572, accession no. STN Database accession no. 2000:894626
DATABASE CAPLUS [online] 19 July 2002 (2002-07-19), GOODMAN S ET AL: "Pharmaceutical compositions comprising Receptor tyrosine Kinase-inhibiting antibodies and angiogenesis inhibitors for treating cancer and metastasis", XP002903573, accession no. STN Database accession no. 2002:539555
BURKE A P ET AL: "Cilengitide Targeting of alphavbeta3 Integrin Receptor Synergizes with Radioimmunotherapy to Increase Efficacy and Apoptosis in Brest Cancer Xenografts1", CANCER RESEARCH, vol. 62, no. 15, 1 August 2002 (2002-08-01), pages 4263 - 4272, XP002903574
DATABASE CAPLUS [online] 7 July 2000 (2000-07-07), MCKEARN J P ET AL: "Method of using an intergrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia", XP002903570, accession no. stn Database accession no. 2000:456866
DATABASE CAPLUS [online] 7 July 2000 (2000-07-07), MCKEARN J P ET AL: "Use of a matrix metalloproteinase inhibitor and an integrin antagonist in the treatment of neoplasia", XP002903571, accession no. STN Database accession no. 2000:456916
DATABASE CAPLUS [online] 12 March 2000 (2000-03-12), DENARDO S J ET AL: "Neovascular targeting with cyclic RGD peptide (cRGDf-ACHA) to enhance delivery of radioimmunotherapy", XP002903567, accession no. STN Database accession no. 2000:162464
DATABASE CAPLUS [online] 21 December 2000 (2000-12-21), KESSLER H ET AL: "Recent progress in the field of .alpha.v-integrin antagonists", XP002903572, accession no. STN Database accession no. 2000:894626
DATABASE CAPLUS [online] 19 July 2002 (2002-07-19), GOODMAN S ET AL: "Pharmaceutical compositions comprising Receptor tyrosine Kinase-inhibiting antibodies and angiogenesis inhibitors for treating cancer and metastasis", XP002903573, accession no. STN Database accession no. 2002:539555
BURKE A P ET AL: "Cilengitide Targeting of alphavbeta3 Integrin Receptor Synergizes with Radioimmunotherapy to Increase Efficacy and Apoptosis in Brest Cancer Xenografts1", CANCER RESEARCH, vol. 62, no. 15, 1 August 2002 (2002-08-01), pages 4263 - 4272, XP002903574
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