METHOD FOR TREATMENT OF OBESITY USING PROLACTIN MODULATORS AND DIET

Title:

METHOD FOR TREATMENT OF OBESITY USING PROLACTIN MODULATORS AND DIET

Document Type and Number:

WIPO Patent Application WO/1995/018614

Kind Code:

A1

Abstract:

The present invention is directed to an improvement in a method of weight and/or body-fat reduction comprising a (preferably moderate) reduction in the caloric intake of a subject in need of such treatment in combination with administration to said subject of a prolactin inhibitor. Additionally, the present invention is directed to an improvement in a method for altering and/or resetting prolactin profiles (and thereby controlling one or more metabolic disorders such as obesity, excessive body fat, hyperlipidemia, hyperlipoproteinemia, hyperglycemia, hypercholesterolemia, hyperinsulinemia, insulin resistance, glucose intolerance, and Type II diabetes) comprising administration to a subject in need of such treatment of a prolactin inhibitor at a predetermined time or times during a 24-hour period in combination with a (preferably moderate) reduction of the caloric intake of said subject.

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Inventors:

CINCOTTA ANTHONY H
MEIER ALBERT H

Application Number:

PCT/US1995/000663

Publication Date:

July 13, 1995

Filing Date:

January 06, 1995

Export Citation:

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Assignee:

ERGO SCIENCE INC (US)
UNIV LOUISIANA STATE (US)

International Classes:

A61K31/00; C07D519/02; A61K31/13; A61K31/135; A61K31/137; A61K31/15; A61K31/166; A61K31/195; A61K31/221; A61K31/35; A61K31/352; A61K31/40; A61K31/405; A61K31/435; A61K31/439; A61K31/44; A61K31/445; A61K31/4515; A61K31/454; A61K31/46; A61K31/475; A61K31/48; A61K31/54; A61K31/5415; A61K31/55; A61K31/551; A61K31/5513; A61K31/695; A61K38/22; A61K45/00; A61K45/06; A61P3/04; A61P3/06; A61P3/08; A61P43/00; G01N33/74; (IPC1-7): A61K31/44

Foreign References:

US4783469A

1988-11-08

Other References:

EXPERIENTIA, Volume 48, issued 1992, (Basel, SWZ), A.H. MEIER et al., "Timed Bromocriptine Administration Reduces Body Fat Stores in Obese Subject and Hyperglycemia in Type II Diabetes", pages 249-253.

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