Title:
METHOD OF USING DIKETOPIPERAZINES AND COMPOSITION CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO2002011676
Kind Code:
A3
Abstract:
The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of formula (1) wherein R<1> and R<2> are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
Inventors:
BAR-OR DAVID
CURTIS C GERALD
RAO NAGARAJA K R
THOMAS GREG
CURTIS C GERALD
RAO NAGARAJA K R
THOMAS GREG
Application Number:
PCT/US2001/041541
Publication Date:
June 06, 2002
Filing Date:
August 02, 2001
Export Citation:
Assignee:
DMI BIOSCIENCES INC (US)
International Classes:
A61K31/495; A61K31/496; A61P7/02; A61P11/00; A61P11/06; A61P29/00; A61P31/00; A61P31/04; A61P37/08; A61P43/00; (IPC1-7): A61K31/495; A61P7/02; C07D241/04
Foreign References:
| US5932579A | 1999-08-03 | |||
| US5817751A | 1998-10-06 |
Other References:
SHIMIZAKI N. ET AL.: "Diketopiperazines as a new class of platelet-activating factor inhibitors", J. MED. CHEM., vol. 30, 1987, pages 1706 - 1709, XP001063996
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