Title:
METHOD OF UTILIZING PHYSIOLOGICAL ACTIVITY OF RARE SACCHARIDE AND COMPOSITIONS CONTAINING RARE SACCHARIDE
Document Type and Number:
WIPO Patent Application WO/2003/097820
Kind Code:
A1
Abstract:
A method of utilizing the physiological activity of a rare saccharide characterized in that physiological activity-sensitive cells are treated with the rare saccharide to modify the function of the cells; and a composition containing a rare saccharide as the active ingredient which has an effect of introducing the rare saccharide into physiological activity-sensitive cells to thereby modify the function of the cells. The above-described cells are human cells. The above-described composition is a functional food, a drug or a cosmetic. The above-described rare saccharide is a rare saccharide belonging to aldoses and/or ketoses. The above-described aldose is D-allose and the above-described cells are selected from the group consisting of cancer cell proliferation inhibitory activity-sensitive cells and active oxygen production inhibitory activity-sensitive cells. The above-described ketose is D-psicose and the above-described cells are selected from the group consisting of chemokine secretion inhibitory activity-sensitive cells, microglia migration inhibitory activity-sensitive cells and hypoglycemic activity-sensitive cells.
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Inventors:
IZUMORI KEN (JP)
TOKUDA MASAAKI (JP)
ITANO TOSHIFUMI (JP)
MIYAMOTO OSAMU (JP)
ISHIDA TOSHIHIKO (JP)
MURAO KOJI (JP)
TASAKA TAIZO (JP)
MUNEUCHI GAN (JP)
YAMAGUCHI FUMINORI (JP)
TANAKA TERUKAZU (JP)
HOSSAIN MOHAMMAD AKRAM (JP)
UEKI MASAAKI (JP)
HIROOKA KAZUYUKI (JP)
TAMINATO ASAHIKO (JP)
TSUSAKI KEIJI (JP)
TAKAHASHI TAKEO (JP)
NAGATA MITSUHIRO (JP)
ISHIDA YUTAKA (JP)
TOKUDA MASAAKI (JP)
ITANO TOSHIFUMI (JP)
MIYAMOTO OSAMU (JP)
ISHIDA TOSHIHIKO (JP)
MURAO KOJI (JP)
TASAKA TAIZO (JP)
MUNEUCHI GAN (JP)
YAMAGUCHI FUMINORI (JP)
TANAKA TERUKAZU (JP)
HOSSAIN MOHAMMAD AKRAM (JP)
UEKI MASAAKI (JP)
HIROOKA KAZUYUKI (JP)
TAMINATO ASAHIKO (JP)
TSUSAKI KEIJI (JP)
TAKAHASHI TAKEO (JP)
NAGATA MITSUHIRO (JP)
ISHIDA YUTAKA (JP)
Application Number:
PCT/JP2003/006405
Publication Date:
November 27, 2003
Filing Date:
May 22, 2003
Export Citation:
Assignee:
FUSHIMI PHARMACEUTICAL CO LTD (JP)
TEIKOKU SEIYAKU KK (JP)
JAPAN REPRESENTED BY PRESIDENT (JP)
SHIKOKU RESEARCH INST INC (JP)
HAYASHIBARA BIOCHEM LAB (JP)
IZUMORI KEN (JP)
TOKUDA MASAAKI (JP)
ITANO TOSHIFUMI (JP)
MIYAMOTO OSAMU (JP)
ISHIDA TOSHIHIKO (JP)
MURAO KOJI (JP)
TASAKA TAIZO (JP)
MUNEUCHI GAN (JP)
YAMAGUCHI FUMINORI (JP)
TANAKA TERUKAZU (JP)
HOSSAIN MOHAMMAD AKRAM (JP)
UEKI MASAAKI (JP)
HIROOKA KAZUYUKI (JP)
TAMINATO ASAHIKO (JP)
TSUSAKI KEIJI (JP)
TAKAHASHI TAKEO (JP)
NAGATA MITSUHIRO (JP)
ISHIDA YUTAKA (JP)
TEIKOKU SEIYAKU KK (JP)
JAPAN REPRESENTED BY PRESIDENT (JP)
SHIKOKU RESEARCH INST INC (JP)
HAYASHIBARA BIOCHEM LAB (JP)
IZUMORI KEN (JP)
TOKUDA MASAAKI (JP)
ITANO TOSHIFUMI (JP)
MIYAMOTO OSAMU (JP)
ISHIDA TOSHIHIKO (JP)
MURAO KOJI (JP)
TASAKA TAIZO (JP)
MUNEUCHI GAN (JP)
YAMAGUCHI FUMINORI (JP)
TANAKA TERUKAZU (JP)
HOSSAIN MOHAMMAD AKRAM (JP)
UEKI MASAAKI (JP)
HIROOKA KAZUYUKI (JP)
TAMINATO ASAHIKO (JP)
TSUSAKI KEIJI (JP)
TAKAHASHI TAKEO (JP)
NAGATA MITSUHIRO (JP)
ISHIDA YUTAKA (JP)
International Classes:
A23L1/09; A23L1/30; A61K8/60; A61K31/7004; A61Q19/00; C12N5/08; (IPC1-7): C12N5/08; A23L1/30; A61K7/00; A61K31/7004
Foreign References:
| JP2002017392A | 2002-01-22 |
Other References:
SEKITANI KEIZO: "Kishoto D-psicose to no kosanka kino", NIHON SHOKUHIN KAGAKU KOGAKUKAI TAIKAI KOENSHU, vol. 48, 2001, pages 107, XP002904611
PRATT S.E. ET AL.: "Evidence that modulation of glucose transporter intrinsic activity is the mechanism involved in the allose-mediated depression of hexose transport in mammalian cells", J. CELL. PHYSIOL., vol. 161, no. 3, 1994, pages 580 - 588, XP002973183
MATUO T. ET AL.: "D-psicose is a rare sugar that provides no energy to growing rats", J. NUTR. SCI. VITAMINOL, vol. 48, no. 1, February 2002 (2002-02-01), TOKYO, pages 77 - 80, XP002973184
NANIMORI KEN ET AL.: "Kishoto no seisan keikaku to seihin-ka no kanosei", FOOD PROCESSING, vol. 38, no. 1, 1 January 2003 (2003-01-01), pages 66 - 69, XP002904612
TOKUDA MASAAKI ET AL.: "D-allose no kassei sanso sansei seigyo sayo ni motozuku zoki kyoketsu hogo sayo", SEIKAGAKU, vol. 74, no. 8, 25 August 2002 (2002-08-25), pages 1063, XP002904613
T. MATSUO: "Less Body Fat Accumulation with D-Psicose Diet versus D-Fructose Diet", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, vol. 30, 2001, pages 55 - 65, XP003003027
TATSUHIRO MATSUO: "Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats", ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, vol. 10, pages 233 - 237, XP002430681, DOI: doi:10.1046/j.1440-6047.2001.00246.x
SEIKITANI KEIZO: "Kishoto D-psicose to no kosanka kino", NIHON SHOKUHIN KAGAKU KOGAKUKAI TAIKAI KOENSHU, vol. 48, 2001, pages 107, XP002904611
T. MATSUO: "D-psicose is a rare sugar that provides no energy to growing rats", J. NUTR. SCI. VITAMINOL., vol. 48, no. 1, February 2002 (2002-02-01), pages 77 - 80, XP002973184
SHAKKAWAT, HOSSAIN, BHUIYAN ET AL., JOURNAL OF FERMENTATION AND BIOENGINEERING, vol. 85, 1998, pages 539 - 541
See also references of EP 1538200A1
PRATT S.E. ET AL.: "Evidence that modulation of glucose transporter intrinsic activity is the mechanism involved in the allose-mediated depression of hexose transport in mammalian cells", J. CELL. PHYSIOL., vol. 161, no. 3, 1994, pages 580 - 588, XP002973183
MATUO T. ET AL.: "D-psicose is a rare sugar that provides no energy to growing rats", J. NUTR. SCI. VITAMINOL, vol. 48, no. 1, February 2002 (2002-02-01), TOKYO, pages 77 - 80, XP002973184
NANIMORI KEN ET AL.: "Kishoto no seisan keikaku to seihin-ka no kanosei", FOOD PROCESSING, vol. 38, no. 1, 1 January 2003 (2003-01-01), pages 66 - 69, XP002904612
TOKUDA MASAAKI ET AL.: "D-allose no kassei sanso sansei seigyo sayo ni motozuku zoki kyoketsu hogo sayo", SEIKAGAKU, vol. 74, no. 8, 25 August 2002 (2002-08-25), pages 1063, XP002904613
T. MATSUO: "Less Body Fat Accumulation with D-Psicose Diet versus D-Fructose Diet", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, vol. 30, 2001, pages 55 - 65, XP003003027
TATSUHIRO MATSUO: "Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats", ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, vol. 10, pages 233 - 237, XP002430681, DOI: doi:10.1046/j.1440-6047.2001.00246.x
SEIKITANI KEIZO: "Kishoto D-psicose to no kosanka kino", NIHON SHOKUHIN KAGAKU KOGAKUKAI TAIKAI KOENSHU, vol. 48, 2001, pages 107, XP002904611
T. MATSUO: "D-psicose is a rare sugar that provides no energy to growing rats", J. NUTR. SCI. VITAMINOL., vol. 48, no. 1, February 2002 (2002-02-01), pages 77 - 80, XP002973184
SHAKKAWAT, HOSSAIN, BHUIYAN ET AL., JOURNAL OF FERMENTATION AND BIOENGINEERING, vol. 85, 1998, pages 539 - 541
See also references of EP 1538200A1
Attorney, Agent or Firm:
Sudo, Asako (Kajino-Cho Koganei-Shi, Tokyo, JP)
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