Title:
METHODS FOR ASSESSING AND TREATING LEUKEMIA
Document Type and Number:
WIPO Patent Application WO2003038129
Kind Code:
A3
Abstract:
Methods for treating leukemia patients include analyzing gene expression profiles of a patient to determine whether the patient is likely to respond to treatment with farnesyl transferase inhibitor (FTI) and, optionally, other therapeutics. The methods are also useful for monitoring patient therapy and for selecting a course of therapy. Genes modulated in response to FTI treatment are provided and are used for formulating the profiles.
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Inventors:
RAPONI MITCH
Application Number:
PCT/US2002/034784
Publication Date:
September 10, 2004
Filing Date:
October 30, 2002
Export Citation:
Assignee:
ORTHO CLINICAL DIAGNOSTICS INC (US)
International Classes:
A61K31/4709; A61K31/473; A61K31/4738; A61K45/00; A61P35/02; C12Q1/68; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO2001055170A1 | 2001-08-02 | |||
| WO2001088850A2 | 2001-11-22 |
Other References:
RININGER J A ET AL: "Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity", DRUG DISCOVERY TODAY 01 DEC 2000 UNITED KINGDOM, vol. 5, no. 12, 1 December 2000 (2000-12-01), pages 560 - 568, XP002249959, ISSN: 1359-6446
BAILEY D S ET AL: "Pharmacogenomics - it's not just pharmacogenetics.", CURRENT OPINION IN BIOTECHNOLOGY. ENGLAND DEC 1998, vol. 9, no. 6, December 1998 (1998-12-01), pages 595 - 601, XP002249960, ISSN: 0958-1669
ROWINSKY ERIC K ET AL: "Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 11, November 1999 (1999-11-01), pages 3631 - 3652, XP008020349, ISSN: 0732-183X
BEAUPRE DARRIN M ET AL: "RAS inhibitors in hematologic cancers: Biologic considerations and clinical applications.", INVESTIGATIONAL NEW DRUGS, vol. 17, no. 2, 1999, pages 137 - 143, XP008020350, ISSN: 0167-6997
BEAUPRE DARRIN M ET AL: "RAS and leukemia: From basic mechanisms to gene-directed therapy.", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 3, March 1999 (1999-03-01), pages 1071 - 1079, XP008020353, ISSN: 0732-183X
BAILEY D S ET AL: "Pharmacogenomics - it's not just pharmacogenetics.", CURRENT OPINION IN BIOTECHNOLOGY. ENGLAND DEC 1998, vol. 9, no. 6, December 1998 (1998-12-01), pages 595 - 601, XP002249960, ISSN: 0958-1669
ROWINSKY ERIC K ET AL: "Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 11, November 1999 (1999-11-01), pages 3631 - 3652, XP008020349, ISSN: 0732-183X
BEAUPRE DARRIN M ET AL: "RAS inhibitors in hematologic cancers: Biologic considerations and clinical applications.", INVESTIGATIONAL NEW DRUGS, vol. 17, no. 2, 1999, pages 137 - 143, XP008020350, ISSN: 0167-6997
BEAUPRE DARRIN M ET AL: "RAS and leukemia: From basic mechanisms to gene-directed therapy.", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 3, March 1999 (1999-03-01), pages 1071 - 1079, XP008020353, ISSN: 0732-183X
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