METHODS OF CANCER TREATMENT AND PREVENTION THROUGH THE MODULATION OF SIRT4 ACTIVITY

Title:

METHODS OF CANCER TREATMENT AND PREVENTION THROUGH THE MODULATION OF SIRT4 ACTIVITY

Document Type and Number:

WIPO Patent Application WO/2012/170664

Kind Code:

A3

Abstract:

The present invention relates to methods of preventing or treating cancer through the use of agents that enhance the activity or expression of SIRT4.

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Inventors:

HAIGIS MARCIA C (US)
JEONG SEUNGMIN (US)

Application Number:

PCT/US2012/041304

Publication Date:

June 13, 2013

Filing Date:

June 07, 2012

Export Citation:

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Assignee:

HARVARD COLLEGE (US)
HAIGIS MARCIA C (US)
JEONG SEUNGMIN (US)

International Classes:

A61K48/00; A61K31/7088; A61K31/7105; A61P35/00

Foreign References:

US20090137681A1

2009-05-28

Other References:

XIE ET AL.: "Sirtuin expression is downregulated in non-small cell lung cancer", FASEB JOURNAL, vol. 24, no. 567.3, April 2010 (2010-04-01)
HAIGIS ET AL.: "SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells", CELL, vol. 126, 8 September 2006 (2006-09-08), pages 941 - 954, XP002598399
AHUJA ET AL.: "Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 46, 16 November 2007 (2007-11-16), pages 33583 - 33592, XP002598398

Attorney, Agent or Firm:

SMITH, DeAnn, F. et al. (LLPPatent Group,155 Seaport Boulevar, Boston MA, US)

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