Title:
METHODS AND COMPOSITIONS FOR CONTROL OF BONE FORMATION VIA MODULATION OF LEPTIN ACTIVITY
Document Type and Number:
WIPO Patent Application WO2000076552
Kind Code:
A8
Abstract:
The invention relates to the method for treatment, diagnosis and prevention of bone disease and comprises methods including inhibiting or increasing leptin synthesis, leptin receptor synthesis, leptin binding to the leptin receptor, and leptin receptor activity. The invention also relates to screening assays to identify compounds that modulate leptin and/or leptin receptor activity. The invention further relates to gene therapy methods utilizing leptin and leptin-related sequences for the treatment and prevention of bone disease.
Inventors:
KARSENTY GERARD
DUCY PATRICIA
AMLING MICHAEL
DUCY PATRICIA
AMLING MICHAEL
Application Number:
PCT/US2000/015911
Publication Date:
July 05, 2001
Filing Date:
June 09, 2000
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
International Classes:
G01N33/50; A61K31/21; A61K31/565; A61K31/711; A61K38/00; A61K38/17; A61K38/22; A61K38/43; A61K38/55; A61K38/57; A61K39/395; A61K45/00; A61K48/00; A61P19/08; A61P19/10; A61P43/00; C12Q1/02; G01N33/15; G01N33/566; G01N33/74; (IPC1-7): A61K48/00; A61K38/00; A61K39/395; C07H21/02; C07H21/04; C12Q1/68; G01N33/53
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