Title:
METHODS AND COMPOSITIONS FOR DECREASING MITOCHONDRIAL OVERPRODUCTION OF REACTIVE OXYGEN SPECIES IN CELLS
Document Type and Number:
WIPO Patent Application WO2000023568
Kind Code:
A3
Abstract:
The subject invention provides means of identifying agents identified as capable of reducing levels of ROS or ROS level correlated indicators such as levels of LPs, AGEs, NF kappa B, PKC, or aldose reductase activation in insulin-independent cells grown under high glucose conditions.
Inventors:
BROWNLEE MICHAEL (US)
Application Number:
PCT/US1999/015734
Publication Date:
September 14, 2000
Filing Date:
July 12, 1999
Export Citation:
Assignee:
BROWNLEE MICHAEL (US)
International Classes:
A61K31/122; A61K31/15; A61K31/409; A61K31/515; A61K31/522; G01N33/50; G01N33/68; (IPC1-7): G01N33/50; A61K31/12; A61K31/15; A61K31/40; A61K31/515; A61K31/52; A61P3/10
Domestic Patent References:
| WO1998027426A1 | 1998-06-25 | |||
| WO1999000123A1 | 1999-01-07 |
Other References:
KING, G.L. AND BROWNLE, M.: "The cellualr and molecular mechanisms of diabetic complications", ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, vol. 25, no. 2, June 1996 (1996-06-01), pages 255 - 270, XP000878790
CURCIO, F. AND CERIELLO, A.: "Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: new insights on the pathophysiological mechanisms of diabetic vascular complications.", IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY, vol. 28A, no. 11-12, November 1992 (1992-11-01) - December 1992 (1992-12-01), pages 787 - 790, XP000879178
GIARDINO, I. ET AL.: "BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.", JOURNAL OF CLINICAL INVESTIGATION, vol. 97, no. 6, March 1996 (1996-03-01), pages 1422 - 1428, XP000879169
ELLIS, E.A. ET AL.: "Increased NADH oxidase activity in the retina of the BBZ/WOR diabetic rat", FREE RADICAL BIOLOGY AND MEDICINE, vol. 24, no. 1, 1 January 1998 (1998-01-01), pages 111 - 120, XP000879172
DATABASE WPI Section Ch Week 199308, Derwent World Patents Index; Class B05, AN 1993-061598[08], XP002131312, "New drug for preventing and treating diabetic complications comprises 1,4-benzoquinone or its hydroquinone form; treats nephropathy, neuropathy, arteriosclerosis etc."
CURCIO, F. AND CERIELLO, A.: "Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: new insights on the pathophysiological mechanisms of diabetic vascular complications.", IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY, vol. 28A, no. 11-12, November 1992 (1992-11-01) - December 1992 (1992-12-01), pages 787 - 790, XP000879178
GIARDINO, I. ET AL.: "BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.", JOURNAL OF CLINICAL INVESTIGATION, vol. 97, no. 6, March 1996 (1996-03-01), pages 1422 - 1428, XP000879169
ELLIS, E.A. ET AL.: "Increased NADH oxidase activity in the retina of the BBZ/WOR diabetic rat", FREE RADICAL BIOLOGY AND MEDICINE, vol. 24, no. 1, 1 January 1998 (1998-01-01), pages 111 - 120, XP000879172
DATABASE WPI Section Ch Week 199308, Derwent World Patents Index; Class B05, AN 1993-061598[08], XP002131312, "New drug for preventing and treating diabetic complications comprises 1,4-benzoquinone or its hydroquinone form; treats nephropathy, neuropathy, arteriosclerosis etc."
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