Title:
METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF BODY WEIGHT DISORDERS, INCLUDING OBESITY
Document Type and Number:
WIPO Patent Application WO2000005373
Kind Code:
A3
Abstract:
The present invention relates to mammalian mahogany genes, including the human mahogany gene, which are novel genes involved in the control of mammalian body weight. The invention encompasses nucleotide sequences of the mahogany gene, host cell expression systems of the mahogany gene, and hosts which have been transformed by these expression systems, including transgenic animals. The invention also encompasses novel mahogany gene products, including mahogany proteins, polypeptides and peptides containing amino acid sequences mahogany proteins, fusion proteins of mahogany proteins polypeptides and peptides, and antibodies directed against such mahogany gene products. The present invention also relates to methods and compositions for the diagnosis and treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia, and for the identification of subjects susceptible to such disorders. Further, the invention relates to methods of using the mahogany gene and gene products of the invention for the identification of compounds which modulate the expression of the mahogany gene and/or the activity of the mahogany gene product. Such compounds can be useful as therapeutic agents in the treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia.
Inventors:
MOORE KAREN
NAGLE DEBORAH L
NAGLE DEBORAH L
Application Number:
PCT/US1999/016484
Publication Date:
June 29, 2000
Filing Date:
July 21, 1999
Export Citation:
Assignee:
MILLENIUM PHARMACEUTICALS INC (US)
International Classes:
C07K14/47; C12N15/12; (IPC1-7): C12N15/12; C07K14/705; A61K38/17; G01N33/68; C07K16/28
Other References:
NAGASE ET AL.: "Prediction of the coding sequences of unidentified human genes IX: the complete sequences of 100 new clones from brain which can code for large proteins in vitro", DNA RESEARCH, vol. 5, 1998, pages 31 - 39, XP000884356
DATABASE GENBAN 10 April 1998 (1998-04-10), NAGASE ET AL.: "Prediction of the coding sequences of unidentified human genes", XP002135391
NAGLE ET AL.: "The mahogany protein is a receptor involved in suppression of obesity", NATURE, vol. 398, 11 March 1999 (1999-03-11), pages 148 - 152, XP002135389
GUNN ET AL.: "The mouse mahogany locus encodes a transmembrane form of attractin", NATURE, vol. 398, 11 March 1999 (1999-03-11), pages 152 - 156, XP002135390
DUKE-COHAN ET AL.: "A novel form of dipeptidylpeptidase IV found in human serum", J. BIOL. CHEM., vol. 270, no. 23, 9 June 1995 (1995-06-09), pages 14107 - 14114, XP000579864
DATABASE GENBAN 10 April 1998 (1998-04-10), NAGASE ET AL.: "Prediction of the coding sequences of unidentified human genes", XP002135391
NAGLE ET AL.: "The mahogany protein is a receptor involved in suppression of obesity", NATURE, vol. 398, 11 March 1999 (1999-03-11), pages 148 - 152, XP002135389
GUNN ET AL.: "The mouse mahogany locus encodes a transmembrane form of attractin", NATURE, vol. 398, 11 March 1999 (1999-03-11), pages 152 - 156, XP002135390
DUKE-COHAN ET AL.: "A novel form of dipeptidylpeptidase IV found in human serum", J. BIOL. CHEM., vol. 270, no. 23, 9 June 1995 (1995-06-09), pages 14107 - 14114, XP000579864
Download PDF: