Title:
METHODS AND COMPOSITIONS FOR GENERATING CHIMERIC ANTIGEN RECEPTOR-MONOCYTES/MACROPHAGES
Document Type and Number:
WIPO Patent Application WO/2024/026455
Kind Code:
A3
Abstract:
The present disclosure relates, in part, to methods and compositions for generating monocytes, macrophages, and/or precursors thereof (such as an induced pluripotent stem cell), comprising (i) a chimeric antigen receptor (CAR); (ii) a polynucleotide encoding a CAR; (iii) a CAR polypeptide; and/or (iv) a vector comprising a polynucleotide encoding a CAR. Methods for treating a cancer using cells expressing the CAR are also provided herein. In some embodiments, the cells expressing the CAR comprise a genetic disruption of a S1RPA gene, CISH gene, and/or SIGLEC10 gene.
Inventors:
HUH CHRISTINE (US)
PARVIZ FERESHTEH (US)
RODGERS DAVID (US)
SUMI MAY (US)
THAYER MATTHEW (US)
WANG HUAFENG (US)
PARVIZ FERESHTEH (US)
RODGERS DAVID (US)
SUMI MAY (US)
THAYER MATTHEW (US)
WANG HUAFENG (US)
Application Number:
PCT/US2023/071207
Publication Date:
April 18, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
SHORELINE BIOSCIENCES INC (US)
International Classes:
C12N15/62; A61K35/15; A61K38/16; A61P35/00; C07K14/705; C07K16/30; C12N15/86; C07K19/00; C12N5/10; C12N15/113
Attorney, Agent or Firm:
GEORGE, Nikolaos, C. et al. (US)
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