Title:
METHODS AND COMPOSITIONS FOR HEAT SHOCK PROTEIN MEDIATED IMMUNOTHERAPY OF MELANOMA
Document Type and Number:
WIPO Patent Application WO2001078655
Kind Code:
A3
Abstract:
The present invention relates to immunotherapeutic compositions comprising an effective amount of a molecular chaperone such as a heat shock protein, preferably hsp70, non-covalently bound to one or more javelinized melanoma antigens and to methods of using the immunotherapeutic compositions to induce an immune response against melanoma in a subject. The immunotherapeutic composition may contain one or more heat shock proteins, such as one or more of hsp70, hsp90, gp96, BiP, and hsp40, and may contain one or more javelinized melanoma antigens.
Inventors:
HOUGHTON ALAN (US)
LIVINGSTON PHILIP (US)
AL-AWQATI QAIS (US)
MAYHEW MARK (US)
HOE MEE (US)
LIVINGSTON PHILIP (US)
AL-AWQATI QAIS (US)
MAYHEW MARK (US)
HOE MEE (US)
Application Number:
PCT/US2001/012449
Publication Date:
March 14, 2002
Filing Date:
April 17, 2001
Export Citation:
Assignee:
HOUGHTON ALAN (US)
LIVINGSTON PHILIP (US)
AL AWQATI QAIS (US)
MAYHEW MARK (US)
HOE MEE (US)
LIVINGSTON PHILIP (US)
AL AWQATI QAIS (US)
MAYHEW MARK (US)
HOE MEE (US)
International Classes:
A61K39/00; A61K39/295; A61P31/04; A61P31/12; A61P35/00; A61P37/00; A61P37/04; C12N15/09; C07K14/47; C07K19/00; (IPC1-7): A61K38/00; A61K38/02; A61K38/16; A61K39/00; C07K4/12; C07K14/00; C07K17/02
Other References:
MOROI Y. ET AL.: "Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 7, 28 March 2000 (2000-03-28), pages 3845 - 3490, XP002947018
KOENEN-WAISMAN S. ET AL.: "Self heat-shock protein (hsp60) peptide serves in a conjugate vaccine against a lethal pneumococcal infection", JOURNAL OF INFECTIOUS DISEASES, vol. 179, no. 2, February 1999 (1999-02-01), pages 403 - 413, XP002947019
HEIKEMA A. ET AL.: "Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides", IMMUNOLOGY LETTERS, vol. 57, no. 1-3, 1997, pages 69 - 74, XP002947020
SRIVASTAVA P.K. ET AL.: "Heat-shock protein-peptide complexes in cancer immunotherapy", CURRENT OPINION IN IMMUNOLOGY, vol. 6, no. 5, 1994, pages 728 - 732, XP002947021
BLACHERE N.E. ET AL.: "Heat shock protein vaccines against cancer", JOURNAL OF IMMUNOTHERAPY, vol. 14, no. 4, 1993, pages 352 - 356, XP002037576
DATABASE CANCERLIT [online] LEWIS J. ET AL.: "Pilot trial of vaccination with autologous tumor-derived gp96 heat shock protein-peptide complex (HSPPC-96) in patients with resected pancreatic adenocarcinoma", XP002947022, Database accession no. 1999701679
CHEN C.H. ET AL.: "Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene", CANCER RESEARCH, vol. 60, no. 4, 2000, pages 1035 - 1042, XP002947023
CASTELLI C. ET AL.: "Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells", CANCER RESEARCH, vol. 61, no. 1, 2001, pages 222 - 227, XP002947024
KOENEN-WAISMAN S. ET AL.: "Self heat-shock protein (hsp60) peptide serves in a conjugate vaccine against a lethal pneumococcal infection", JOURNAL OF INFECTIOUS DISEASES, vol. 179, no. 2, February 1999 (1999-02-01), pages 403 - 413, XP002947019
HEIKEMA A. ET AL.: "Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides", IMMUNOLOGY LETTERS, vol. 57, no. 1-3, 1997, pages 69 - 74, XP002947020
SRIVASTAVA P.K. ET AL.: "Heat-shock protein-peptide complexes in cancer immunotherapy", CURRENT OPINION IN IMMUNOLOGY, vol. 6, no. 5, 1994, pages 728 - 732, XP002947021
BLACHERE N.E. ET AL.: "Heat shock protein vaccines against cancer", JOURNAL OF IMMUNOTHERAPY, vol. 14, no. 4, 1993, pages 352 - 356, XP002037576
DATABASE CANCERLIT [online] LEWIS J. ET AL.: "Pilot trial of vaccination with autologous tumor-derived gp96 heat shock protein-peptide complex (HSPPC-96) in patients with resected pancreatic adenocarcinoma", XP002947022, Database accession no. 1999701679
CHEN C.H. ET AL.: "Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene", CANCER RESEARCH, vol. 60, no. 4, 2000, pages 1035 - 1042, XP002947023
CASTELLI C. ET AL.: "Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells", CANCER RESEARCH, vol. 61, no. 1, 2001, pages 222 - 227, XP002947024
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