Title:
METHODS AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS
Document Type and Number:
WIPO Patent Application WO2001062725
Kind Code:
A3
Abstract:
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
Inventors:
BOUCK NOEL P
DAWSON DAVID W
GILLIS PAUL R
CRAWFORD SUSAN E
STELLMACH VERONICA M
VOLPERT OLGA
DAWSON DAVID W
GILLIS PAUL R
CRAWFORD SUSAN E
STELLMACH VERONICA M
VOLPERT OLGA
Application Number:
PCT/US2001/005915
Publication Date:
March 21, 2002
Filing Date:
February 22, 2001
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
International Classes:
C12N15/09; A61K38/00; A61K38/57; A61K45/00; A61P15/00; A61P17/00; A61P27/02; A61P35/00; A61P43/00; C12N5/07; C12N5/079; C12N5/09; C12N5/10; G01N33/574; G01N33/68; A61K48/00; (IPC1-7): A61K38/16
Domestic Patent References:
| WO1993024529A1 | 1993-12-09 | |||
| WO1995033480A1 | 1995-12-14 |
Other References:
See also references of EP 1265627A4
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