Title:
Methods and compositions for inhibiting bacterial growth
Document Type and Number:
WIPO Patent Application WO1998014567
Kind Code:
A3
Abstract:
The present invention relates generally to the field of bacteriology. More particularly, it concerns methods and compositions for the treatment of bacterial infection employing oligonucleotides targeted to the Shine-Dalgarno region of prokaryotes to inhibit bacterial protein expression and hence inhibit bacterial infection.
Inventors:
MARTIN WILLIAM J (US)
WISNIOWSKI PAUL (US)
WISNIOWSKI PAUL (US)
Application Number:
PCT/US1997/018094
Publication Date:
July 16, 1998
Filing Date:
September 30, 1997
Export Citation:
Assignee:
MARTIN WILLIAM J (US)
WISNIOWSKI PAUL (US)
ADVANCED RES & TECH INST (US)
WISNIOWSKI PAUL (US)
ADVANCED RES & TECH INST (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C12N15/11; A61K31/70; A61K47/22; C07H21/00
Domestic Patent References:
| WO1990000624A1 | 1990-01-25 | |||
| WO1993023570A1 | 1993-11-25 | |||
| WO1996024378A2 | 1996-08-15 | |||
| WO1995027054A1 | 1995-10-12 |
Foreign References:
| EP0140308A2 | 1985-05-08 |
Other References:
TOSCHKA, H. ET AL.: "Complete nucleotide sequence of a 16S ribosomal RNA from Pseudomonas aeruginosa", NUCLEIC ACIDS RESEARCH., vol. 16, 1988, OXFORD GB, pages 2348, XP002055330
RAHMAN M A ET AL: "ANTIBACTERIAL ACTIVITY AND INHIBITION OF PROTEIN SYNTHESIS IN ESCHERICHIA COLI BY ANTISENSE DNA ANALOGS", ANTISENSE RESEARCH AND DEVELOPMENT, vol. 1, 1991, pages 319 - 327, XP002045888
THIERRY A R ET AL: "LIPOSOMAL DELIVERY AS A NEW APPROACH TO TRANSPORT ANTISENSE OLIGONUCLEOTIDES", GENE REGULATION, BIOLOGY OF ANTISENSE RNA AND DNA, 1992, ERICKSON R P;IZANT J G, pages 147 - 161, XP002040368
TANIGUCHI, T. & WEISSMANN, C.: "Inhibition of Qbeta RNA 70S ribosome intiation complex formation by an oligonucleotide complementary to the 3' terminal region of E.coli 16S ribosomal RNA", NATURE., vol. 275, 26 October 1978 (1978-10-26), LONDON GB, pages 770 - 772, XP002055331
JAYARAMAN K ET AL: "SELECTIVE INHIBITION OF ESCHERICHIA COLI PROTEIN SYNTHESIS AND GROWTH BY NONIONIC OLIGONUCLEOTIDES COMPLEMENTARY TO THE 3' END OF 16S RRNA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 78, no. 3, March 1981 (1981-03-01), pages 1537 - 1541, XP002045889
RAHMAN M A ET AL: "ANTIBACTERIAL ACTIVITY AND INHIBITION OF PROTEIN SYNTHESIS IN ESCHERICHIA COLI BY ANTISENSE DNA ANALOGS", ANTISENSE RESEARCH AND DEVELOPMENT, vol. 1, 1991, pages 319 - 327, XP002045888
THIERRY A R ET AL: "LIPOSOMAL DELIVERY AS A NEW APPROACH TO TRANSPORT ANTISENSE OLIGONUCLEOTIDES", GENE REGULATION, BIOLOGY OF ANTISENSE RNA AND DNA, 1992, ERICKSON R P;IZANT J G, pages 147 - 161, XP002040368
TANIGUCHI, T. & WEISSMANN, C.: "Inhibition of Qbeta RNA 70S ribosome intiation complex formation by an oligonucleotide complementary to the 3' terminal region of E.coli 16S ribosomal RNA", NATURE., vol. 275, 26 October 1978 (1978-10-26), LONDON GB, pages 770 - 772, XP002055331
JAYARAMAN K ET AL: "SELECTIVE INHIBITION OF ESCHERICHIA COLI PROTEIN SYNTHESIS AND GROWTH BY NONIONIC OLIGONUCLEOTIDES COMPLEMENTARY TO THE 3' END OF 16S RRNA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 78, no. 3, March 1981 (1981-03-01), pages 1537 - 1541, XP002045889
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