Title:
METHODS AND COMPOSITIONS FOR INHIBITING THE NUCLEAR FACTOR kB PATHWAY
Document Type and Number:
WIPO Patent Application WO/2012/011103
Kind Code:
A3
Abstract:
The current invention provides therapeutic methods which include inhibition of nuclear factor κb pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing different diseases such as cancer, inflammation, and virus infections.
Inventors:
GOLAN AVI (IL)
GOPAS JACOB (IL)
OZER JANET (IL)
EISNER NADAV (IL)
BACHER ADELBERT (DE)
EISENREICH WOLFGANG (DE)
OSTROZHENKOVA ELENA (DE)
WINER HILA (IL)
GOPAS JACOB (IL)
OZER JANET (IL)
EISNER NADAV (IL)
BACHER ADELBERT (DE)
EISENREICH WOLFGANG (DE)
OSTROZHENKOVA ELENA (DE)
WINER HILA (IL)
Application Number:
PCT/IL2011/000576
Publication Date:
July 05, 2012
Filing Date:
July 19, 2011
Export Citation:
Assignee:
UNIV BEN GURION (IL)
MOR RESEARCH APPLIC LTD (IL)
GOLAN AVI (IL)
GOPAS JACOB (IL)
OZER JANET (IL)
EISNER NADAV (IL)
BACHER ADELBERT (DE)
EISENREICH WOLFGANG (DE)
OSTROZHENKOVA ELENA (DE)
WINER HILA (IL)
MOR RESEARCH APPLIC LTD (IL)
GOLAN AVI (IL)
GOPAS JACOB (IL)
OZER JANET (IL)
EISNER NADAV (IL)
BACHER ADELBERT (DE)
EISENREICH WOLFGANG (DE)
OSTROZHENKOVA ELENA (DE)
WINER HILA (IL)
International Classes:
C07D495/00; A61K33/243; C07D495/22
Foreign References:
| JP2002047146A | 2002-02-12 | |||
| US5876728A | 1999-03-02 | |||
| US20070118916A1 | 2007-05-24 | |||
| US4775405A | 1988-10-04 |
Other References:
AKINJOGUNLA ET AL.: "Antimicrobial potential of Nymphaea lotus (Nymphaeaceae) against wound pathogens", JOURNAL OF MEDICINAL PLANTS RESEARCH, vol. 3, no. 3, March 2009 (2009-03-01), pages 138 - 141, Retrieved from the Internet
LOHI ET AL.: "Antibacterial properties of Nymphaea lotus (Nymphaeaceae) tuber extract against clinical and phyto pathogens", JOURNAL OF PHARMACY RESEARCH, vol. 4, no. 4, 12 May 2010 (2010-05-12), pages 1231 - 1233, XP009172978
CHAUHAN ET AL.: "Pharmacological Evaluation For The Antifertility Effect of the Ethanolic Seed Extract of Nelumbo Nucifera (Sacred Lotus)", PHARMACOLOGYONLINE, vol. 2, 2009, pages 636 - 643, XP009172657
EFFERTH: "Natural products pave their way in cancer therapy", CANCER BIOLOGY & THERAPY, vol. 8, no. 19, 1 October 2009 (2009-10-01), pages 1869 - 1870, XP009172656, DOI: doi:10.4161/cbt.8.19.9691
LOHI ET AL.: "Antibacterial properties of Nymphaea lotus (Nymphaeaceae) tuber extract against clinical and phyto pathogens", JOURNAL OF PHARMACY RESEARCH, vol. 4, no. 4, 12 May 2010 (2010-05-12), pages 1231 - 1233, XP009172978
CHAUHAN ET AL.: "Pharmacological Evaluation For The Antifertility Effect of the Ethanolic Seed Extract of Nelumbo Nucifera (Sacred Lotus)", PHARMACOLOGYONLINE, vol. 2, 2009, pages 636 - 643, XP009172657
EFFERTH: "Natural products pave their way in cancer therapy", CANCER BIOLOGY & THERAPY, vol. 8, no. 19, 1 October 2009 (2009-10-01), pages 1869 - 1870, XP009172656, DOI: doi:10.4161/cbt.8.19.9691
Attorney, Agent or Firm:
PEARL COHEN ZEDEK LATZER et al. (P.O Box, 46733 Herzlia, IL)
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