Title:
METHODS AND COMPOSITIONS FOR INHIBITING ABAD/Aß PROTEIN INTERACTION
Document Type and Number:
WIPO Patent Application WO2005117538
Kind Code:
A9
Abstract:
This invention provides methods, compositions and articles of manufacture for inhibiting binding between Aß protein and ABAD in cells. Uses of this invention include, for example, treating Alzheimer's disease; reducing free radical generation, DNA fragmentation, and cytochrome C release in cells; and preserving cell viability by preventing LDH release from a cell.
Inventors:
YAN SHI DU (US)
STERN DAVID M (US)
LUSTBADER JOYCE W (US)
WU HAO (US)
STERN DAVID M (US)
LUSTBADER JOYCE W (US)
WU HAO (US)
Application Number:
PCT/US2005/012482
Publication Date:
March 16, 2006
Filing Date:
April 12, 2005
Export Citation:
Assignee:
UNIV COLUMBIA (US)
CORNELL RES FOUNDATION INC (US)
CORNELL RES FOUNDATION INC (US)
International Classes:
C07K14/00; A01N37/18; A61K38/00; C07K1/00; C07K17/00; G01N33/567
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