Title:
METHODS, COMPOSITIONS, AND KITS FOR PRODUCING SKELETAL MUSCLE STEM CELLS AND TREATING DISORDERS
Document Type and Number:
WIPO Patent Application WO/2020/206272
Kind Code:
A3
Abstract:
Provided herein are, inter alia, are methods, compositions and kits for producing populations of myogenic progenitor cells, and compositions comprising the cell populations derived thereof. Also included are methods and compositions for treating or preventing a muscle disease or disorder in a subject (e.g., Duchenne muscular dystrophy (DMD)).
Inventors:
LEE GABSANG (US)
WAGNER KATHRYN (US)
SUN CONGSHAN (US)
CHOI INYOUNG (US)
LIM HO TAE (US)
ANDERSEN PETER (US)
WAGNER KATHRYN (US)
SUN CONGSHAN (US)
CHOI INYOUNG (US)
LIM HO TAE (US)
ANDERSEN PETER (US)
Application Number:
PCT/US2020/026603
Publication Date:
November 19, 2020
Filing Date:
April 03, 2020
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
C12N5/00; A01N63/00; C12N5/02; C12N5/071; G01N33/567
Foreign References:
| US20180273906A1 | 2018-09-27 | |||
| US20150166961A1 | 2015-06-18 |
Other References:
ZYGMUNT ET AL.: "Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans", MOL CELL BIOL., vol. 37, no. 10, 2017, pages e00426 - 16, XP055761142
REED ET AL.: "Response of turkey muscle satellite cells to thermal challenge . I. transcriptome effects in proliferating cells", BMC GENOMICS, vol. 18, 2017, pages 352, XP055761143
WONG ET AL.: "Abstract 15: Motor Denervation Activates Muscle Stem Cells and Leads to Muscle TGFbeta Expression", PLAST RECONSTR SURG GLOB OPEN, vol. 6, 2018, pages 12, XP055761145
BORCHIN ET AL.: "Derivation and FACS-Mediated Purification of PAX3+/PAX7+ Skeletal Muscle Precursors from Human Pluripotent Stem Cells", STEM CELL REPORTS, vol. 1, no. 6, 2013, pages 620 - 631, XP055324367, DOI: 10.1016/j.stemcr.2013.10.007
SARIG ET AL.: "Cloned Myogenic Cells Can Transdifferentiate In Vivo into Neuron-Like Cells", PLOS ONE, vol. 5, no. 1, 2010, pages e8814, XP055761146
LIU ET AL.: "Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration", ELIFE, vol. 6, 2017, pages e26464, XP055761150
REED ET AL.: "Response of turkey muscle satellite cells to thermal challenge . I. transcriptome effects in proliferating cells", BMC GENOMICS, vol. 18, 2017, pages 352, XP055761143
WONG ET AL.: "Abstract 15: Motor Denervation Activates Muscle Stem Cells and Leads to Muscle TGFbeta Expression", PLAST RECONSTR SURG GLOB OPEN, vol. 6, 2018, pages 12, XP055761145
BORCHIN ET AL.: "Derivation and FACS-Mediated Purification of PAX3+/PAX7+ Skeletal Muscle Precursors from Human Pluripotent Stem Cells", STEM CELL REPORTS, vol. 1, no. 6, 2013, pages 620 - 631, XP055324367, DOI: 10.1016/j.stemcr.2013.10.007
SARIG ET AL.: "Cloned Myogenic Cells Can Transdifferentiate In Vivo into Neuron-Like Cells", PLOS ONE, vol. 5, no. 1, 2010, pages e8814, XP055761146
LIU ET AL.: "Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration", ELIFE, vol. 6, 2017, pages e26464, XP055761150
Attorney, Agent or Firm:
CORLESS, Peter (US)
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