Title:
METHODS AND COMPOSITIONS FOR MODULATING APOPTOSIS
Document Type and Number:
WIPO Patent Application WO2004075839
Kind Code:
A3
Abstract:
The invention provides novel modulatory polypeptides of TRAIL-induced apoptosis. The invention also provides methods for screening modulators of TRAIL-induced apoptosis. The methods comprise first screening test agents for modulators of a novel modulatory polypeptide of TRAIL-induced apoptosis and then further screening the identified modulating agents for modulators of TRAIL-induced apoptosis. The invention further provides methods and pharmaceutical compositions for modulating apoptosis of cells and for treating diseases and conditions such as cancers.
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Inventors:
AZA-BLANC PEDRO (US)
COOKE MICHAEL P (US)
DEVERAUX QUINN L (US)
COOPER CHRISTOPHER L (US)
COOKE MICHAEL P (US)
DEVERAUX QUINN L (US)
COOPER CHRISTOPHER L (US)
Application Number:
PCT/US2004/005169
Publication Date:
March 31, 2005
Filing Date:
February 20, 2004
Export Citation:
Assignee:
IRM LLC
AZA-BLANC PEDRO (US)
COOKE MICHAEL P (US)
DEVERAUX QUINN L (US)
COOPER CHRISTOPHER L (US)
AZA-BLANC PEDRO (US)
COOKE MICHAEL P (US)
DEVERAUX QUINN L (US)
COOPER CHRISTOPHER L (US)
International Classes:
C07K5/00; C07K14/00; C07K16/00; C12Q1/68; G01N33/53; G01N33/567; G01N33/574; A61K; (IPC1-7): C12Q1/68; G01N33/53; C07K5/00; C07K14/00; C07K16/00
Other References:
WELDON C.B. ET AL.: "Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray", SURGERY, vol. 132, August 2002 (2002-08-01), pages 293 - 301, XP002280208
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