Title:
METHODS AND COMPOSITIONS FOR MODULATING OXIDIZED LDL TRANSPORT
Document Type and Number:
WIPO Patent Application WO2001094952
Kind Code:
A3
Abstract:
The present invention relates to the fields of biology and pharmacology. This invention relates, generally, to methods and compositions for modulating oxLDL activity or transport. The present invention resides more specifically in methods for screening compounds that modulate oxLDL activity, more particularly oxLDL cellular uptake. The present invention more particularly describes novel methods of selecting or identifying compounds that can modulate oxLDL cellular binding, uptake and/or degradation by CD36 polypeptides and especially CD36 polypeptides comprising a functional cytoplasmic domain in various cells, such as macrophages. The invention also relates to the use of such compounds, in particular for research, development, improvement, diagnosis, therapeutic or prohylactic treatment of various pathological conditions. The invention also relates to the products or compositions, such as CD36 variants, recombinant cells, vectors, kits, and the like, which can be used for implementing the above methods or for therapeutic purposes.
Inventors:
MCGREGOR JOHN (FR)
MALAUD ERIC (FR)
MALAUD ERIC (FR)
Application Number:
PCT/EP2001/006211
Publication Date:
March 28, 2002
Filing Date:
May 31, 2001
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
MCGREGOR JOHN (FR)
MALAUD ERIC (FR)
MCGREGOR JOHN (FR)
MALAUD ERIC (FR)
International Classes:
A01K67/02; A61K45/00; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/02; A01K67/027; A61P9/04; A61P9/10; A61P9/12; A61P31/00; A61P43/00; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/63; C12Q1/02; G01N33/15; G01N33/50; G01N33/92; (IPC1-7): G01N33/92; G01N33/50; C07K14/705; A61P3/06; A01K67/02; C12N15/63; C12N5/10
Domestic Patent References:
| WO1996000288A2 | 1996-01-04 | |||
| WO1997018304A1 | 1997-05-22 |
Other References:
PUENTE NAVAZO MARTA D ET AL: "Identification on human CD36 of a domain (155-183) implicated in binding oxidized low-density lipoproteins (Ox-LDL).", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 16, no. 8, 1996, pages 1033 - 1039, XP001020391, ISSN: 1079-5642
PUENTE NAVAZO MARTA D ET AL: "A domain (155-183) on human CD36 is implicated in the binding of oxidized low density lipoproteins (OxLDL).", BLOOD, vol. 86, no. 10 SUPPL. 1, 15 November 1995 (1995-11-15), 37th Annual Meeting of the American Society of Hematology;Seattle, Washington, USA; December 1-5, 1995, pages 375A, XP001020396, ISSN: 0006-4971
LOUGHEED MARILEE ET AL: "High affinity saturable uptake of oxidized low density lipoprotein by macrophages from mice lacking the scavenger receptor class A type I/II.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 20, 1997, pages 12938 - 12944, XP000961176, ISSN: 0021-9258
YAMAGUCHI ATSUMI ET AL: "PS-liposome and ox-LDL bind to different sites of the immunodominant domain (155-183) of CD36: A study with GS95, a new anti-CD36 monoclonal antibody.", THROMBOSIS RESEARCH., vol. 97, no. 5, 1 March 2000 (2000-03-01), pages 317 - 326, XP000972125, ISSN: 0049-3848
HAN JIHONG ET AL: "Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36.", JOURNAL OF LIPID RESEARCH, vol. 40, no. 5, May 1999 (1999-05-01), pages 830 - 838, XP000972189, ISSN: 0022-2275
KAPLAN MARIELLE ET AL: "Role of macrophage glycosaminoglycans in the cellular catabolism of oxidized LDL by macrophages.", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 18, no. 4, April 1998 (1998-04-01), pages 542 - 553, XP000972166, ISSN: 1079-5642
UITTENBOGAARD ANNETTE ET AL: "High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 15, 14 April 2000 (2000-04-14), pages 11278 - 11283, XP000961129, ISSN: 0021-9258
PUENTE NAVAZO MARTA D ET AL: "A domain (155-183) on human CD36 is implicated in the binding of oxidized low density lipoproteins (OxLDL).", BLOOD, vol. 86, no. 10 SUPPL. 1, 15 November 1995 (1995-11-15), 37th Annual Meeting of the American Society of Hematology;Seattle, Washington, USA; December 1-5, 1995, pages 375A, XP001020396, ISSN: 0006-4971
LOUGHEED MARILEE ET AL: "High affinity saturable uptake of oxidized low density lipoprotein by macrophages from mice lacking the scavenger receptor class A type I/II.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 20, 1997, pages 12938 - 12944, XP000961176, ISSN: 0021-9258
YAMAGUCHI ATSUMI ET AL: "PS-liposome and ox-LDL bind to different sites of the immunodominant domain (155-183) of CD36: A study with GS95, a new anti-CD36 monoclonal antibody.", THROMBOSIS RESEARCH., vol. 97, no. 5, 1 March 2000 (2000-03-01), pages 317 - 326, XP000972125, ISSN: 0049-3848
HAN JIHONG ET AL: "Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36.", JOURNAL OF LIPID RESEARCH, vol. 40, no. 5, May 1999 (1999-05-01), pages 830 - 838, XP000972189, ISSN: 0022-2275
KAPLAN MARIELLE ET AL: "Role of macrophage glycosaminoglycans in the cellular catabolism of oxidized LDL by macrophages.", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 18, no. 4, April 1998 (1998-04-01), pages 542 - 553, XP000972166, ISSN: 1079-5642
UITTENBOGAARD ANNETTE ET AL: "High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 15, 14 April 2000 (2000-04-14), pages 11278 - 11283, XP000961129, ISSN: 0021-9258
Download PDF:
Previous Patent: INHIBITORS OF C-REACTIVE PROTEIN INDUCED INFLAMMATION
Next Patent: PIEZOELECTRIC ROTATIONAL ACCELEROMETER
Next Patent: PIEZOELECTRIC ROTATIONAL ACCELEROMETER