Title:
METHODS AND COMPOSITIONS FOR MODULATING STING SIGNALING AND INNATE IMMUNE RESPONSES
Document Type and Number:
WIPO Patent Application WO/2022/261481
Kind Code:
A3
Abstract:
Provided herein are compositions and methods for enhancing the activity of Stimulator of Interferon Genes (STING) with one or more agents for inhibiting the activity of one or more negative regulators of STING, including DNAJC13 and ESCRT.
Inventors:
HACOHEN NIR (US)
GENTILI MATTEO (US)
LIU BINGXU (US)
GENTILI MATTEO (US)
LIU BINGXU (US)
Application Number:
PCT/US2022/033081
Publication Date:
March 02, 2023
Filing Date:
June 10, 2022
Export Citation:
Assignee:
BROAD INST INC (US)
MASSACHUSETTS INST TECHNOLOGY (US)
MASSACHUSETTS GEN HOSPITAL (US)
MASSACHUSETTS INST TECHNOLOGY (US)
MASSACHUSETTS GEN HOSPITAL (US)
International Classes:
C12N15/113; C07K14/47
Domestic Patent References:
| WO2019067468A1 | 2019-04-04 |
Foreign References:
| US20130039933A1 | 2013-02-14 |
Other References:
BESEMER ANNA S ET AL: "Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 78, no. 2, 22 April 2020 (2020-04-22), pages 645 - 660, XP037362744, ISSN: 1420-682X, DOI: 10.1007/S00018-020-03521-Y
MARTINE GIRARD ET AL: "RME-8 regulates trafficking of the epidermal growth factor receptor", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 582, no. 6, 26 February 2008 (2008-02-26), pages 961 - 966, XP071250584, ISSN: 0014-5793, DOI: 10.1016/J.FEBSLET.2008.02.042
BLAKE A FLOOD ET AL: "STING pathway agonism as a cancer therapeutic", IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 290, no. 1, 29 July 2019 (2019-07-29), pages 24 - 38, XP071456455, ISSN: 0105-2896, DOI: 10.1111/IMR.12765
MARTINE GIRARD ET AL: "RME-8 regulates trafficking of the epidermal growth factor receptor", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 582, no. 6, 26 February 2008 (2008-02-26), pages 961 - 966, XP071250584, ISSN: 0014-5793, DOI: 10.1016/J.FEBSLET.2008.02.042
BLAKE A FLOOD ET AL: "STING pathway agonism as a cancer therapeutic", IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 290, no. 1, 29 July 2019 (2019-07-29), pages 24 - 38, XP071456455, ISSN: 0105-2896, DOI: 10.1111/IMR.12765
Attorney, Agent or Firm:
MCCOOL, Gabriel J. et al. (US)
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