METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS

Title:

METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO2003024926

Kind Code:

A3

Abstract:

The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

Inventors:

TIMMER RICHARD T (US)
ALEXANDER CHRISTOPHER W (US)
PILLARISETTI SIVARAM (US)
SAXENA UDAY (US)
CAMPBELL KAREN A (US)

Application Number:

PCT/US2002/030177

Publication Date:

December 11, 2003

Filing Date:

September 23, 2002

Export Citation:

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Assignee:

REDDY US THERAPEUTICS INC (US)
TIMMER RICHARD T (US)
ALEXANDER CHRISTOPHER W (US)
PILLARISETTI SIVARAM (US)
SAXENA UDAY (US)
CAMPBELL KAREN A (US)

International Classes:

A61K31/35; A61K31/53; A61K31/5377; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07D251/44; C07D251/46; C07D251/48; C07D251/50; C07D251/52; C07D251/70; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/14; C07D453/02; C07D471/08; (IPC1-7): C07D251/44; C07D50/; C07D54/; A61K31/53; A61P29/00; A61P35/00; A61P19/02

Domestic Patent References:

WO1997008156A1

1997-03-06

Other References: