METHODS AND COMPOSITIONS FOR PRODUCING PRIMORDIAL GERM CELL-LIKE CELLS

Title:

METHODS AND COMPOSITIONS FOR PRODUCING PRIMORDIAL GERM CELL-LIKE CELLS

Document Type and Number:

WIPO Patent Application WO/2023/192937

Kind Code:

A3

Abstract:

Provided herein are methods and compositions for differentiating induced pluripotent stem cells into primordial germ cell-like cells by overexpressing transcription factors such as DLX5, HHEX, and/or FIGLA.

Inventors:

KRAMME CHRISTIAN (US)
SMELA MERRICK (US)
CHATTERJEE PRANAM (US)
CHURCH GEORGE (US)

Application Number:

PCT/US2023/065143

Publication Date:

November 09, 2023

Filing Date:

March 30, 2023

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Assignee:

HARVARD COLLEGE (US)

International Classes:

C12N5/0735; C12N15/79; A61K35/12; C12N5/075; C12N5/076

Foreign References:

US20200063105A1	2020-02-27
US20120107284A1	2012-05-03

Other References:

FOSSETT E., KHAN W. S.: "Optimising Human Mesenchymal Stem Cell Numbers for Clinical Application: A Literature Review", STEM CELLS INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, US, vol. 2012, 1 January 2012 (2012-01-01), US , pages 1 - 5, XP093109238, ISSN: 1687-966X, DOI: 10.1155/2012/465259

Attorney, Agent or Firm:

CHANCELLOR, K., Blake et al. (US)

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