METHODS AND COMPOSITIONS RELATED TO IRM COMPOUNDS AND TOLL-LIKE RECEPTOR 8

Title:

METHODS AND COMPOSITIONS RELATED TO IRM COMPOUNDS AND TOLL-LIKE RECEPTOR 8

Document Type and Number:

WIPO Patent Application WO2004071459

Kind Code:

A3

Abstract:

Methods of eliciting a TLR8-mediated cellular response are disclosed. Such methods include administration of either a TLR8 agonist or a TLR8 antagonist to an IRM-responsive cell so that the IRM compound affects at least one TLR8-mediate cellular signaling pathway. In some cases, the method may provide prophylactic or therapeutic treatment for a condition treatable by modulating a TLR8-mediated cellular pathway.

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Inventors:

GORDEN KEITH B (US)
QIU XIAOHONG (US)
VASILAKOS JOHN P (US)

Application Number:

PCT/US2004/004353

Publication Date:

January 27, 2005

Filing Date:

February 12, 2004

Export Citation:

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Assignee:

3M INNOVATIVE PROPERTIES CO (US)
GORDEN KEITH B (US)
QIU XIAOHONG (US)
VASILAKOS JOHN P (US)

International Classes:

A61K31/4745; G01N33/566; (IPC1-7): A01N43/90

Other References:

LEE ET AL.: "Saturated fatty acids activates but polyunsaturated fatty acids inhibits toll-like receptor 2 dimerized with toll-like receptor 6 or 1", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 17, 23 April 2004 (2004-04-23), pages 16971 - 16979, XP002982909
FONTENEAU ET AL.: "Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the Bystander maturation of myeloid dendritic cells", JOURNAL OF VIROLOGY, vol. 78, no. 10, 13 November 2003 (2003-11-13), pages 5223 - 5232, XP002982910
See also references of EP 1592302A4

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