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Title:
METHODS AND COMPOSITIONS RELATING TO GLP1R VARIANTS
Document Type and Number:
WIPO Patent Application WO/2022/046944
Kind Code:
A3
Abstract:
Provided herein are methods and compositions relating to glucagon-like peptide-1 receptor (GLP1R) libraries having nucleic acids encoding for immunoglobulins that bind to GLP1R. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

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Inventors:
SATO AARON (US)
GARG PANKAJ (US)
LIU QIANG (US)
AXELROD FUMIKO (US)
Application Number:
PCT/US2021/047616
Publication Date:
April 07, 2022
Filing Date:
August 25, 2021
Export Citation:
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Assignee:
TWIST BIOSCIENCE CORP (US)
International Classes:
C12P21/08; C07K16/42; G01N33/53
Domestic Patent References:
WO2005018536A22005-03-03
Foreign References:
US20190135926A12019-05-09
US20190062441A12019-02-28
US20170037124A12017-02-09
US20160297883A12016-10-13
US20030223994A12003-12-04
US20050049402A12005-03-03
Attorney, Agent or Firm:
DUSABAN GONZALES, Stephanie S. (US)
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